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The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.

Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Panax ginseng might help with hair growth and has fewer side effects than synthetic treatments.

Skin aging reflects overall body aging and can indicate internal health conditions.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

Targeting colon cancer stem cells might lead to better treatment results.

Wild African goats have genetic adaptations for surviving harsh desert conditions.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

KIF18B is important for correctly positioning cell division machinery in skin cells, affecting hair follicle development.

Higher BPA levels may be linked to idiopathic hyperandrogenemia in women.

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

IMA may indicate oxidative stress in skin and hair disorders, but more research is needed.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Topical minoxidil is the best-supported treatment for female hair loss, but personalized plans are needed.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Avoid chemical and physical damage to protect hair.

Oral zinc sulphate is an effective and safe treatment for thallium poisoning, especially for skin and hair symptoms.

Shift work disrupts the body's natural clock, leading to health problems.

A teenager had both alopecia areata and vitiligo, which are rare to occur together.