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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Herbal remedies can cause adverse effects and need more safety research.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Anorexia and bulimia lead to serious health problems and increased risk of death, requiring aggressive treatment.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Auxin and ethylene hormones both work together and against each other to control plant growth.

The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.

Itraconazole is potentially effective for treating invasive aspergillosis, but more research is needed.