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    Glossary Immune-Mediated

    immune system mistakenly attacks the body's own cells

    Immune-mediated refers to conditions or diseases that are caused by abnormal activity of the immune system, where it mistakenly attacks the body's own cells and tissues. This can lead to various health issues, such as inflammation, tissue damage, and organ dysfunction. Examples include autoimmune diseases like rheumatoid arthritis and alopecia areata, where the immune system targets hair follicles, leading to hair loss.

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    1. Alopecia areata as another immune‐mediated disease developed in patients treated with tumour necrosis factor‐α blocker agents Journal of the European Academy of Dermatology and Venereology · 2010 · 61 citations
    2. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review Nutrients · 2022 · 40 citations
    3. Three cases of immune‐mediated adnexal skin disease treated with cyclosporin Veterinary Dermatology · 2006 · 36 citations
    4. Immune-mediated alopecias and their mechanobiological aspects Cells and Development · 2022 · 17 citations
    5. Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review Dermatology and therapy · 2021 · 16 citations
    6. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023 · 9 citations
    7. Immune‐Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta‐Analysis International Journal of Dermatology · 2025 · 7 citations
    8. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022 · 6 citations
    9. Immune-Mediated Diseases of the Central Nervous System Pediatric Clinics of North America · 2016 · 4 citations
    10. Applications of Antioxidant Nanoparticles in Immune-Mediated Inflammatory Diseases Antioxidants · 2025 · 2 citations
    11. Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study Clinical Cosmetic and Investigational Dermatology · 2024 · 2 citations
    12. Microneedle‐mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia Advanced Materials · 2024 · 2 citations
    13. Immune-Mediated Skin Reactions Induced by Recombinant Antibodies and Other TNF-Alpha Inhibitors InTech eBooks · 2018 · 2 citations
    14. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    15. Iron Deficiency in Immune-Mediated Inflammatory Skin Diseases: A Missing Link Between Systemic Inflammation, Immunometabolism, and Disease Burden Cells · 2026
    16. Advances in Bioprinting to Model Immune‐Mediated Skin Diseases Advanced Healthcare Materials · 2025
    17. Immunopharmacological potential of Arctium lappa L. in immune-mediated skin diseases: A critical review of experimental and clinical evidence Frontiers in Pharmacology · 2025
    18. The suitability of mesenchymal stem cells for treating immune-mediated inflammatory skin diseases: a systematic review Dermatology Reports · 2025
    19. BH17 Bridging the gap: identifying dual-targeting therapies for patients with alopecia areata and coexisting immune-mediated inflammatory diseases British Journal of Dermatology · 2025
    20. THE ROLE OF EXOSOMES IN THE DIAGNOSIS AND TREATMENT OF IMMUNE MEDIATED DERMATOSIS, TREATMENT OF SKIN WOUNDS AND ALOPECIA Vestnik dermatologii i venerologii · 2024
    21. 167 Epidermal GRK2 knockout triggers a hair loss phenotype with features resembling immune-mediated alopecias Journal of Investigative Dermatology · 2023
    22. Addressing Autoimmune and Immune-mediated Skin Disease Burden in Women Women's health issues · 2022
    23. Immune-mediated Coombs negative intravascular haemolysis in systemic lupus erythematosus (SLE) BMJ Case Reports · 2021
    24. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    25. Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse 2016 · 36 citations
    26. Feline immune-mediated skin disorders: Part 1 Journal of Feline Medicine and Surgery · 2025 · 3 citations
    27. Feline immune-mediated skin disorders: Part 2 Journal of Feline Medicine and Surgery · 2025 · 1 citations
    28. UV Protection Habits and Preferences in Patients With Distinct Cutaneous Immune‐Mediated Inflammatory Diseases Photodermatology Photoimmunology & Photomedicine · 2026
    29. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    30. Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata Scholarly Commons (Embry–Riddle Aeronautical University) · 2025