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    Glossary Immune-Mediated Alopecia

    immune system attacks hair follicles, causing hair loss

    Immune-Mediated Alopecia (IMA) is a condition where the body's immune system mistakenly attacks hair follicles, leading to hair loss. This autoimmune response can result in patchy hair loss or more widespread thinning, and it is often seen in conditions like alopecia areata.

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    1. Immune-mediated alopecias and their mechanobiological aspects Cells and Development · 2022 · 17 citations
    2. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022 · 6 citations
    3. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    4. 167 Epidermal GRK2 knockout triggers a hair loss phenotype with features resembling immune-mediated alopecias Journal of Investigative Dermatology · 2023
    5. Alopecia areata as another immune‐mediated disease developed in patients treated with tumour necrosis factor‐α blocker agents Journal of the European Academy of Dermatology and Venereology · 2010 · 61 citations
    6. BH17 Bridging the gap: identifying dual-targeting therapies for patients with alopecia areata and coexisting immune-mediated inflammatory diseases British Journal of Dermatology · 2025
    7. Microneedle‐mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia Advanced Materials · 2024 · 2 citations
    8. Immune‐Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta‐Analysis International Journal of Dermatology · 2025 · 7 citations
    9. THE ROLE OF EXOSOMES IN THE DIAGNOSIS AND TREATMENT OF IMMUNE MEDIATED DERMATOSIS, TREATMENT OF SKIN WOUNDS AND ALOPECIA Vestnik dermatologii i venerologii · 2024
    10. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    11. Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance Frontiers in Medicine · 2026
    12. Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse 2016 · 36 citations
    13. Pathomechanisms of immune-mediated alopecia International Immunology · 2019 · 45 citations
    14. Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata Scholarly Commons (Embry–Riddle Aeronautical University) · 2025
    15. PRP for Immune Mediated Alopecias (Alopecia Areata, Alopecia Totalis) 2021 · 1 citations
    16. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    17. Tofacitinib for the Treatment of Three Immune-mediated Conditions in One Patient: Ulcerative Colitis, Pyoderma Gangrenosum, and Alopecia Areata Inflammatory Bowel Diseases · 2021 · 5 citations
    18. THE USE OF TOFACITINIB IN THE TREATMENT OF IMMUNE-MEDIATED UNIVERSAL ALOPECIA IN A PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE REPORT Anais do Congresso Brasileiro de Reumatologia 2020 · 2021
    19. Frontal Fibrosing Alopecia. An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin? Clinical, cosmetic and investigational dermatology · 2020 · 8 citations
    20. The emergence of Alopecia Areata is not dependent on perforin-mediated cytolysis The Journal of Immunology · 2024
    21. Three cases of immune‐mediated adnexal skin disease treated with cyclosporin Veterinary Dermatology · 2006 · 36 citations
    22. Applications of Antioxidant Nanoparticles in Immune-Mediated Inflammatory Diseases Antioxidants · 2025 · 2 citations
    23. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011 · 54 citations
    24. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review Nutrients · 2022 · 40 citations
    25. Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review Dermatology and therapy · 2021 · 16 citations
    26. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023 · 9 citations
    27. Immune-Mediated Skin Reactions Induced by Recombinant Antibodies and Other TNF-Alpha Inhibitors InTech eBooks · 2018 · 2 citations
    28. The suitability of mesenchymal stem cells for treating immune-mediated inflammatory skin diseases: a systematic review Dermatology Reports · 2025
    29. Addressing Autoimmune and Immune-mediated Skin Disease Burden in Women Women's health issues · 2022
    30. Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures Genomics · 2010 · 61 citations