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research Research Snippets
New hair regrowth model introduced, imiquimod kills skin cancer cells, T-cadherin loss makes skin cancer more invasive, no strong link between PTCH1 gene and skin cancer after transplant, and male teens more likely to have hereditary hair loss.
research Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin
This study found that topical application of partial proteasomal inhibitors accelerates hair growth by stabilizing β-catenin and disrupting the hair cycle's normal balance of activation and quiescence.
research Polycystic ovary syndrome and the differential diagnosis of hyperandrogenism
This review discusses diagnostic criteria for polycystic ovary syndrome and highlights the challenges and risks of misdiagnosing women with other hyperandrogenism causes; it reports no clinical results.
research LB1045 Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo
PP405 may help hair growth by activating hair follicle stem cells.
research Measurement of steroid hormones by liquid chromatography-tandem mass spectrometry with small amounts of hair
This study developed a new method using liquid chromatography-tandem mass spectrometry to measure multiple steroid hormones in hair, requiring significantly fewer strands than previous methods, with high accuracy and precision.
research Clinical, Laboratory, and Radiological Diagnosis of Hyperandrogenism
Hyperandrogenism is diagnosed using clinical signs, lab tests, and imaging.
research ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling
This study found that OCT4-overexpressing human hair follicle mesenchymal stem cells show promise for artificial hematopoiesis by enhancing self-renewal through cytoskeletal remodeling and the beta-catenin-dependent adherens junction pathway.
research 527 PTEN is a master driver of healing inhibition in venous leg ulcers by targeting immune response, angiogenesis and lymphangiogenesis
This study identified PTEN as a key regulator in non-healing venous leg ulcers, suppressing immune responses and lymphangiogenesis, suggesting its potential as a therapeutic target for promoting VLU healing.
research Patient-Based Ratio Method for Permanent Zone Donor Area Calculation in Hair Transplant
This study found that using a specific ratio method based on the patient's scalp measurements can effectively predict the dimensions of the permanent safe zone for hair transplants, particularly in early stages of androgenetic alopecia, potentially ensuring long-lasting transplant results.
research Kisspeptin and LH pulsatile temporal coupling in PCOS patients
This study found that only eumenorrheic polycystic ovary syndrome patients showed a temporal coupling between kisspeptin and luteinizing hormone pulsatile secretions.
research New-onset androgenic alopecia following human chorionic gonadotropic diet and testosterone pellet implantation
This report presents a case of new-onset androgenic alopecia in a patient following the use of the hCG diet combined with testosterone pellet implantation.
research Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance
This study explored the effects of a common Hutchinson-Gilford progeria syndrome mutation in an inducible mouse model, revealing skin abnormalities similar to those in affected patients.
research Spider joint hair sensilla: adaptation to proprioreceptive stimulation
This study found that Cupiennius salei spiders have specialized mechanosensitive hairs on their legs that adaptively respond to joint movements during walking, suggesting a proprioceptive function.
research Non-invasive assessment of hair regeneration in androgenetic alopecia mice in vivo using two-photon and second harmonic generation imaging
This study used non-invasive imaging techniques to assess hair follicle characteristics in AGA mice, revealing delayed hair shaft alternation and growth stages, as well as testosterone-induced follicle miniaturization, offering potential methods for evaluating AGA on human scalps in vivo.
research Testosterone, sex hormone-binding globulin and dehydroepiandrosterone levels and cervical length of Egyptian women with a history of recurrent miscarriages, polycystic ovary syndrome and without the conditions at three stages of pregnancy
This study found that pregnant Egyptian women with PCOS and recurrent miscarriages showed elevated DHEA levels and shortened cervical length, which may negatively impact pregnancy outcomes.
research The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: dose-response studies
This study found that testosterone propionate increased hair mass in female hamsters' flank organs, while cyproterone acetate applied topically reduced androgen-stimulated hair in a dose-dependent manner.
research Polycystic Ovary Syndrome Mimicking an Androgen-Secreting Tumor
This case report suggests that PCOS can present with virilization and rapidly increasing testosterone levels, and highlights oral contraceptives' effectiveness in managing hyperandrogenism in such cases.
research The impact of 1-hour plasma glucose on the metabolic characteristics and pregnancy outcomes in polycystic ovary syndrome
This study found that elevated 1-hour plasma glucose in women with PCOS was associated with increased risk of metabolic disorders and gestational diabetes, indicating it may be a useful marker for adverse metabolic status.
research A case of severe hyperandrogenism, acanthosis nigricans and overt diabetes: the use of non-invasive methods for diagnosis, pathogenesis and management
This article describes a case of severe hyperandrogenism in a 35-year-old woman where high-resolution imaging ruled out tumors, and treatment with cyproterone acetate normalized testosterone levels.
research Steroid 17-Hydroxyprogesterone in Hair Is a Potential Long-Term Biomarker of Androgen Control in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
This study shows that measuring 17-hydroxyprogesterone concentrations in scalp hair may be a useful noninvasive tool for monitoring treatment in adults with congenital adrenal hyperplasia.
research Luteinizing Hormone and Human Chorionic Gonadotropin Decrease Type 2 5α-Reductase and Androgen Receptor Protein Levels in Women’s Skin
This study found that hCG decreased 5α-reductase and androgen receptor levels in skin samples from women in vitro, suggesting that human skin responds to LH/hCG treatment.
research Self-assembled monolayer enhanced support-free two-photon polymerisation for microscale kinematic pairs
This study introduced a high-viscosity epoxy photoresist to enhance the fabrication of complex microstructures with monolithic integration and mechanical stability, enabling advancements in two-photon 3D printing for creating functional micro-mechanical devices.
research HairMeasure: A Cost-Effective Device for Measuring Hair Mass Index
This study describes new devices, "HairMeasure" and "Scalp Zone Identifier," which offer an economical method to calculate Hair Mass Index without disposable materials.
research RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF FINASTERIDE AND TAMSULOSIN IN TABLET FORMULATIONS
This study developed a simple HPLC method for accurately estimating tamsulosin and finasteride in pharmaceutical forms, demonstrating good precision and potential application in combined dosage analysis.
research Principles of management of women with hirsutism – a dermatologist’s perspective
This article presents a clinical approach to diagnosing and managing hirsutism from a dermatological perspective, but it reports no new clinical findings.
research A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix
In this study, researchers found that the prevalent Glu 410 Lys mutation in hHb6 and a new Glu 403 Lys mutation in hHb1 are linked to monilethrix, suggesting a mutational hotspot in type II hair keratins.
research A phosphoinositide-mediated switch of GET pathway receptor dimerization in Arabidopsis
This study identifies the PI4P-RHD4 module as a key regulator of GET pathway receptor dynamics in Arabidopsis, affecting TA protein insertion and root hair growth.
research Hirsutism in young women
This article reviews the assessment, causes, and management approaches for hirsutism in women, emphasizing ethical considerations concerning unapproved drug use and contraceptive responsibility but reports no new clinical findings.
research Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
This review assesses existing knowledge about the 17q21.31 inversion polymorphism, highlighting its genetic structure differences across ancestries, associations with various diseases, and implications for precision medicine and drug discovery.