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Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Men with frontal male pattern baldness may have a higher risk of gastric cancer.

Baldness in men with prostate cancer is linked to higher levels of certain sex hormones, but chest hair density is not.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Men with lower 2nd to 4th finger ratios tend to have larger sinus volumes.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

Chromosomal differences affect how muscle cells respond to testosterone.

Men with testicular cancer were less likely to experience baldness and severe acne.

The index to ring finger ratio may indicate disease severity in female ankylosing spondylitis patients, but not in males.

Men with male pattern baldness may have a higher risk of heart disease due to increased levels of a specific lipid in their blood.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

Scalp hair sweating is a significant predictor of hair cortisol levels.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Finasteride treats baldness but may cause lasting sexual side effects.

Cosmetic hair treatments can increase hair testosterone levels, while natural hair color does not affect it.

Hair levels of estradiol and progesterone are higher in premenopausal than postmenopausal women, but the difference isn't statistically significant, indicating the need for a better measurement method.

Oral contraceptives provide various health benefits beyond birth control, including managing menstrual issues, skin conditions, pain, and reducing the risk of certain cancers.

Hormones and stretching both needed for nipple area skin growth in mice.

Human skin's melanocytes respond to light by changing shape, producing pigments and hormones, which may affect sleep patterns.

Mice with autoimmune hair loss showed signs of heart problems.

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.