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The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

The fuzzy gene is crucial for controlling hair growth cycles.

New genetic mutations linked to rare skin disorders were found in three newborns.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

Metreleptin treatment significantly improved metabolic health in a boy with congenital generalized lipodystrophy.

Two mutations in KRT74 and EDAR genes cause sheep to have finer wool.

A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

Hairless mice lack fur due to a genetic mutation affecting skin response, not hormone issues.

A man with KID syndrome developed a rare cancer in a long-term skin infection.

Personalized thiopurine dosing based on NUDT15 genotyping can improve long-term outcomes for ulcerative colitis and Crohn's disease patients.

Cats with abnormal hair had DSG4 gene changes causing hair problems.

A specific genetic change in the KRT71 gene causes a hair loss condition in Hereford cattle.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

Genetic testing for EGFR mutations is crucial in similar cases.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

Harlequin mutant mice have hair loss due to low AIF protein levels and retroviral element activity.

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Mutations in TBX3 cause horses to have more even hair color instead of Dun camouflage.

Using special RNA to target a mutant gene fixed hair problems in mice.

Targeted siRNA therapy may be a promising treatment for KID syndrome by reducing mutant gene expression and improving cell communication.

Oral contraceptives lower testosterone levels in women, especially those with certain genetic traits, and may be linked to increased breast cancer risk.

Bald thigh syndrome in sighthounds is caused by structural defects in hair shafts due to downregulated genes and proteins.

A new gene mutation causes vitamin D-resistant rickets and hair loss in two siblings.

Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.

A mouse gene mutation increases the risk of skin cancer.