Sebaceous Carcinoma Arising at a Chronic Candidiasis Skin Lesion of a Patient with Keratitis-Ichthyosis-Deafness (KID) Syndrome

    December 2011 in “ British Journal of Dermatology ”
    Yo Kaku, Hideaki Tanizaki, Miki Tanioka, Jun‐ichi Sakabe, Aya Miyagawa‐Hayashino, Y. Tokura, Yoshiki Miyachi, Kenji Kabashima
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    TLDR A man with KID syndrome developed a rare cancer in a long-term skin infection.
    The document described a unique case of a 30-year-old Japanese man with keratitis-ichthyosis-deafness (KID) syndrome who developed sebaceous carcinoma within a chronic candidiasis skin lesion after over 10 years of treatment with oral fluconazole. The carcinoma, which appeared as a nodule on his left buttock at age 20 and later became erosive, was confirmed through histological examination. The patient exhibited typical KID syndrome symptoms and had a heterozygous genetic mutation linked to the condition. After switching to oral itraconazole therapy, there was a reduction in hyperkeratotic plaques. The case highlighted the need for careful malignancy screening in KID syndrome patients due to the unusual early onset and location of the sebaceous carcinoma.
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