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The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Skin problems are common and important signs of eating disorders and treating the eating disorder can improve these skin conditions.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

Spironolactone might help protect against severe lung problems in COVID-19 patients.

The document concludes that there is no agreed-upon best method for measuring drug delivery within hair follicles and more research is needed to validate current techniques.

Eating disorders can cause skin problems that need treating the underlying condition for better health.

People with psoriasis are more likely to have Metabolic Syndrome than those without psoriasis.

Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Hormonal treatments can improve acne, but they come with potential side effects and risks.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

Treatment can improve survival and symptoms in dogs with Cushing's disease, but outcomes are unpredictable.

The study aims to find the best treatment for central serous chorioretinopathy by comparing various options.

COVID-19 might worsen symptoms and progression of benign prostatic hyperplasia, possibly due to inflammation and metabolic disturbances in the prostate gland. More research is needed to confirm this.

Hormonal therapies help treat female hair loss, but results are slow and vary.

New drugs are improving treatment for hormone-related diseases in small pets.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Using systemic drugs as creams for skin conditions shows promise, but more research is needed to confirm their effectiveness and safety.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.