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    Glossary Half-Life

    Half-life refers to the time required for the concentration of a substance, such as a drug or hormone, to reduce to half its initial value. In the context of hair loss and hair biology, understanding the half-life of hormones like dihydrotestosterone (DHT) is crucial, as prolonged exposure to elevated levels can contribute to conditions like androgenetic alopecia. Key distinguishing characteristics of half-life include its dependence on metabolic processes and the implications it has for treatment efficacy and timing in hair loss therapies.

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    1. The Pharmacokinetics of 2.5- to 10-mg Oral Doses of Minoxidil in Healthy Volunteers The Journal of Clinical Pharmacology · 1989 · 25 citations
    2. Bioequivalance of single oral administration of finasteride tablet and capsule in healthy volunteers 2004
    3. The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men European Journal of Pharmaceutical Sciences · 2008 · 33 citations
    4. Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy Annals of Neurology · 2003 · 30 citations
    5. Sublingual tofacitinib for alopecia areata: a roll‐over pilot clinical trial and analysis of pharmacokinetics International Journal of Dermatology · 2021 · 9 citations
    6. Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: A descriptive monocentric study Dermatologic Therapy · 2019 · 6 citations
    7. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    8. 24 ARQ-234: a high affinity CD200-Fc fusion protein for the treatment of atopic dermatitis 2023
    9. Nanocarriers for Improved Delivery of Angiotensin-(1-7) Elsevier eBooks · 2015
    10. Quality of Life and the Presence of Depression Among Adults with Hair Loss in the South of Saudi Arabia Psychology Research and Behavior Management · 2022 · 5 citations
    11. Life Style of Female Students Nurses with Iron Deficiency Anemia Egyptian Journal of Health Care · 2022
    12. Quality of life in children with scalp hair loss: a Clinico-epidemiological study Egyptian Journal of Dermatology and Venerology · 2026
    13. The Association Between Hair Loss and COVID-19: The Impact of Hair Loss After COVID-19 Infection on the Quality of Life Among Residents in Saudi Arabia Cureus · 2022 · 1 citations
    14. The prevalence of skin diseases in Greece, impact on quality of life and stigmatization: A population‐based survey study JEADV Clinical Practice · 2023 · 2 citations
    15. Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data Dermatology and Therapy · 2023
    16. Enhancing Quality of Life and Sexual Functioning in Female Androgenetic Alopecia: Therapeutic Potential of Hair Follicle-Derived Stem Cells Healthcare · 2024
    17. Lower urinary tract symptoms (LUTS): The role of medications in improvement of quality of life Galenika Medical Journal · 2022
    18. Validation of Chinese Version of Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (Chi-PCOSQ) PLoS ONE · 2016 · 12 citations
    19. Alopecia induced by CDK 4/6 Inhibitors and its Impact on the Quality of Life of Patients with advanced Breast cancer 2025
    20. EVALUATING THE IMPACT OF SKIN DISEASES ON ANXIETY, DEPRESSION, LONELINESS AND QUALITY OF LIFE 2025
    21. 15485 Evaluating the safety and efficacy of intense pulsed light with radiofrequency in US patients with hidradenitis suppurativa: A split-body study Journal of the American Academy of Dermatology · 2020
    22. Nail and hair changes in chronic kidney disease patients Medpulse International Journal of Medicine · 2020
    23. Perceived Stigma and Mental Health Disorders Among Adults With Alopecia Areata Living in Japan The Journal of Dermatology · 2025 · 1 citations
    24. Dermatologists’ Perspectives and Real-World Assessment of Alopecia Areata Severity, Burden, and Healthcare Resource Utilization in Adults in the Kingdom of Saudi Arabia Dermatology and Therapy · 2026
    25. Beyond Hair Preservation: Scalp Cooling as a Biopsychosocial Intervention in Patients Receiving Highly Alopecia-Inducing Chemotherapy (Preprint) 2026
    26. The Prevalence of Complementary and Alternative Medications Use Among Dermatology Patients in Aseer Region, Saudi Arabia Clinical Cosmetic and Investigational Dermatology · 2022 · 3 citations
    27. Public Awareness of the Symptoms and Risk Factors of Thyroid Disease in Saudi Arabia Cureus · 2024
    28. Hair Australasian Journal of Dermatology · 2024
    29. Androgenetic alopecia: Traditional cardiovascular risk factors, metabolic syndrome, and component traits among Nigerian adults Nigerian Journal of Clinical Practice · 2023
    30. Depression among Alopecia Areata Patients: Prevalence and associated factors in a Tunisian sample La Tunisie Médicale · 2024