146 citations,
May 2002 in “The American journal of pathology” Cathepsin L is essential for normal hair growth and development.
124 citations,
August 1994 in “Journal of Investigative Dermatology” Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.
120 citations,
November 2014 in “Biological Reviews” The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.
115 citations,
August 2008 in “The Journal of Clinical Endocrinology & Metabolism” Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.
111 citations,
March 1951 in “Annals of the New York Academy of Sciences” Understanding the mouse hair cycle is crucial for cancer research.
109 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.
102 citations,
February 2008 in “The FASEB Journal” One minoxidil-sensitive potassium channel exists in human hair follicles.
93 citations,
April 2003 in “Proceedings of the National Academy of Sciences of the United States of America” Fatty acid transport protein 4 is essential for skin and hair development.
86 citations,
July 2020 in “International Journal of Molecular Sciences” Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.
64 citations,
July 1997 in “Journal of The American Academy of Dermatology” Finding eosinophils near hair bulbs helps diagnose alopecia areata.
62 citations,
January 2000 in “Developmental dynamics” Notch-related genes play a key role in the development and cycling of hair follicles.
59 citations,
May 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
59 citations,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.
46 citations,
June 2018 in “American Journal of Clinical Dermatology” Hair loss is common in lupus patients and can be permanent or reversible, depending on the type, with various treatments available.
46 citations,
January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.
46 citations,
May 1986 in “Seminars in Reproductive Medicine” Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.
45 citations,
December 1991 in “Annals of the New York Academy of Sciences” ECM molecules are crucial for hair growth and development.
43 citations,
November 2007 in “Dermatologic Clinics” Hair and nail changes can indicate health issues, including cancer and side effects from cancer treatments.
41 citations,
October 2008 in “The American journal of pathology” Blocking a specific protein signal can make hair grow on mouse nipples.
40 citations,
October 2002 in “Endocrinology” Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.
39 citations,
September 2013 in “Journal of Cosmetic Dermatology” Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.
35 citations,
October 2012 in “Dermatologic Clinics” Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.
35 citations,
April 2008 in “Human Molecular Genetics” Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.
33 citations,
January 1997 in “Endocrinology” Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
32 citations,
February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
28 citations,
March 2016 in “Toxicologic pathology” Dogs could be good models for studying human hair growth and hair loss.
26 citations,
March 1986 in “Clinical and Experimental Dermatology” Scalp hair grows at 0.37 mm/day, forearm hair at 0.18 mm/day, and thigh hair at 0.30 mm/day, with no significant differences found in people with certain hair conditions.
25 citations,
November 2014 in “British Journal of Dermatology” Certain transporters are found in human hair follicles and may affect hair growth and loss.
24 citations,
September 2002 in “Dermatologic Surgery” The place where hair is transplanted can affect its growth and survival rates.
23 citations,
January 2016 in “Transgender health” Hormone therapy with estradiol and spironolactone can regrow scalp hair in transgender women by lowering testosterone to female levels.