546 citations,
February 2008 in “PLANT PHYSIOLOGY” OsPHR2 gene causes excessive phosphate in rice shoots, affecting plant growth and root development.
17 citations,
July 2013 in “Amino Acids” The study investigated the role of elevated ornithine decarboxylase (ODC) activity in skin tumorigenesis, particularly its effect on bulge stem cells and polyamine catabolic metabolites, using ODC-ER transgenic mice. It was found that increased ODC activity promoted skin tumor development by recruiting bulge stem cells, which are associated with hair follicles, rather than through the generation of reactive oxygen species (ROS) by polyamine catabolic oxidases. Inhibiting polyamine catabolic oxidase activity with MDL72527 resulted in a shorter tumor latency, increased tumor burden, and higher conversion to carcinomas, indicating that the tumorigenic effect was not due to ROS generation. The findings suggested that targeting ODC activity could be a potential strategy for preventing skin tumorigenesis by affecting stem cell dynamics rather than through the toxicity of polyamine breakdown products.
5 citations,
September 2013 in “BMB Reports” BMPR1a-ECD reduces wrinkles much more effectively than retinoic acid.
4 citations,
May 2020 in “Annals of palliative medicine” Plum blossom needle acupuncture with qi-invigorating therapy is more effective for Seborrheic Alopecia than Western medicine.
1 citations,
November 2022 in “Anais Brasileiros de Dermatologia” Many hospitalized children with COVID-19 had skin, mouth, or nail changes, with skin rashes being common.
December 2023 in “International journal of molecular sciences” Chromosomal differences affect how muscle cells respond to testosterone.
47 citations,
June 2013 in “Biology of blood and marrow transplantation” Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.
5 citations,
January 2020 in “Current Pharmaceutical Design” Geranium plants have healing properties like fighting microbes, protecting the liver, reducing inflammation, and may help with viruses, stomach issues, and diabetes.
2 citations,
July 2022 in “Frontiers in Cardiovascular Medicine” Forsythiasides have multiple health benefits but may cause pseudoallergic reactions, and more research is needed.
2 citations,
January 2022 in “The Application of Clinical Genetics” A young Russian girl with Meier-Gorlin syndrome has two new mutations in the CDC6 gene.
1 citations,
November 2022 in “Animals” The research found specific genes and pathways that control fur development and color in young American minks.
7 citations,
January 2021 in “Frontiers in genetics” Inherited color dilution in rabbits is linked to DNA methylation changes.
52 citations,
February 2003 in “Archives of dermatology” 9-cis-retinoic acid showed some effectiveness in treating AIDS-related Kaposi sarcoma but had significant side effects at higher doses.
8 citations,
February 2021 in “Comprehensive psychiatry” People with trichotillomania or skin picking disorder generally sleep worse than those without these conditions.
5 citations,
January 2016 in “Open Journal of Regenerative Medicine” Myoblast transplantation shows promise for treating various muscle and heart conditions.
August 2024 in “Receptors” Vitamin D receptor is crucial for skin wound healing.
May 2017 in “American Society of Health-System Pharmacists eBooks” 383 citations,
February 2011 in “Nature Reviews Genetics” DNA profiling in forensics has improved, but predicting physical traits and ancestry from DNA has limitations and requires ethical consideration.
82 citations,
June 2020 in “Inflammation Research” Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.
50 citations,
May 2019 in “Drugs” Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.
41 citations,
March 2010 in “Psychology Research and Behavior Management” Using psychological treatments can help manage skin conditions along with regular medical care.
19 citations,
January 2018 in “Scientific Reports” Non-immune factors play a significant role in alopecia areata.
11 citations,
January 2000 in “Journal of Cutaneous Pathology” Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.
5 citations,
February 2010 in “Expert Review of Dermatology” Treating both the mind and skin together, especially by managing stress, can greatly improve outcomes for skin disorders linked to psychological issues.
1 citations,
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Melanocyte-associated antigens may play a key role in alopecia areata and could be targets for new treatments.
April 2019 in “Journal of Investigative Dermatology” Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.
171 citations,
October 1990 in “Alcoholism/Alcoholism, clinical and experimental research” The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.
113 citations,
July 2020 in “Communications biology” Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.
73 citations,
April 2013 in “Stem cells” LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.
68 citations,
March 2019 in “Advanced Healthcare Materials” Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.