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    Glossary Hair Pigmentation

    natural hair color determined by melanin in hair follicles

    Hair pigmentation refers to the natural color of hair, which is determined by the type and amount of melanin produced by melanocytes in the hair follicles. There are two main types of melanin: eumelanin, which gives hair black or brown color, and pheomelanin, which imparts red or yellow hues. The balance and concentration of these pigments result in the wide variety of hair colors seen in humans.

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    1. Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias Scientific Reports · 2017 · 23 citations
    2. 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes Frontiers in cell and developmental biology · 2020 · 13 citations
    3. Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses Nature Genetics · 2015 · 73 citations
    4. UDP-GlcNAc-1-Phosphotransferase Is a Clinically Important Regulator of Human and Mouse Hair Pigmentation Journal of Investigative Dermatology · 2021 · 10 citations
    5. Hair Coloration by Gene Regulation: Fact or Fiction? Trends in biotechnology · 2015 · 15 citations
    6. Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology Medizinische Genetik · 2023
    7. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008 · 115 citations
    8. Gray Hair: From Preventive to Treatment Clinical Cosmetic and Investigational Dermatology · 2025
    9. The Peripheral Clock Regulates Human Pigmentation 2014 · 81 citations
    10. The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle 2015 · 15 citations
    11. Hair Follicles as a Critical Model for Monitoring the Circadian Clock International Journal of Molecular Sciences · 2023 · 5 citations
    12. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations
    13. Human hair production by scalp samples grafted onto nude mice. Biochemical data on normal human hair and the genetic defect trichothiodystrophy Journal of Dermatological Science · 1994 · 2 citations
    14. Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle PloS one · 2015 · 31 citations
    15. Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice The Journal of Nutritional Biochemistry · 2011 · 29 citations
    16. 4th Intercontinental Meeting of Hair Research Societies 2004 The "World of Hair" Journal der Deutschen Dermatologischen Gesellschaft · 2004 · 1 citations
    17. Transcriptomic crossroads: Decoding genes and pathways that connect alopecia areata with chronic inflammatory skin disorders JID Innovations · 2026
    18. Rhamnose-mediated modulation of hair follicle growth: insights from chemical genomics bioRxiv (Cold Spring Harbor Laboratory) · 2025
    19. Expression and Analysis of TBX3 Gene in the Skin from Three Locations on Dun Mongolian Bider Horse Genes · 2024
    20. Gene Editing Technologies in Aesthetic Dermatology—Mechanisms, Emerging Applications, and Patient Safety Paradigms 2025
    21. Genetics of blond hair Nature Genetics · 2012
    22. Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche Yearbook of Dermatology and Dermatologic Surgery · 2006
    23. New frontiers in human hair follicle (neuro‐)endocrinology Experimental dermatology · 2006
    24. Fundamental hair follicle biology and fine fibre production in animals animal · 2010 · 170 citations
    25. Gene Expression During Drosophila Wing Morphogenesis and Differentiation Genetics · 2005 · 57 citations
    26. Control by a hair’s breadth: the role of microRNAs in the skin Cellular and Molecular Life Sciences · 2012 · 41 citations
    27. miRNA in regulation of skin and hair follicle development Yichuan · 2013 · 6 citations
    28. Natural course of epidermolysis bullosa simplex with mottled pigmentation in a Japanese family with the p.P25L mutation in <i> KRT 5 </i> Journal of Dermatology · 2019 · 3 citations
    29. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
    30. 1363 Hair follicle growth and pigmentation during ageing Journal of Investigative Dermatology · 2018