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    Glossary Hair Follicle Bulge

    specific region housing stem cells for hair growth

    The hair follicle bulge is a specific region located in the outer root sheath of the hair follicle. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration, as well as for repairing the skin after injury. This area is essential for the cyclical nature of hair growth and plays a significant role in conditions like alopecia.

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    1. The Krüppel-like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation Journal of Biological Chemistry · 2003 · 88 citations
    2. Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts Journal of Investigative Dermatology · 1995 · 11 citations
    3. <i>In vitro</i> interactions between sensory nerves, epidermis, hair follicles and capillaries in a tissue‐engineered reconstructed skin Experimental Dermatology · 2004
    4. 1333 Spheroids cell cultures as a promising study model for hair follice regeneration Journal of Investigative Dermatology · 2018
    5. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005 · 205 citations
    6. The development of an in vitro human hair follicle organoid with a complexity similar to that in vivo Biomedical materials · 2024
    7. Hair development and Langerhans cell migration during human embryogenesis Journal of dermatological science · 2012
    8. Tissue-Engineered Skin Preserving the Potential of Epithelial Cells to Differentiate into Hair After Grafting Tissue Engineering Part A · 2010 · 24 citations
    9. Sostdc1 defines the size and number of skin appendage placodes Developmental biology · 2012 · 56 citations
    10. Effects of Administration of Vitamin a to Pregnant Dams on the Skin of the Fetuses of Albino Mice 2014
    11. Hedgehog-Wnt Interactions during Pathologic Epithelial Bud Development and Skin Tumorigenesis. Deep Blue (University of Michigan) · 2008
    12. Preparing the hair follicle canal for hair shaft emergence Experimental dermatology · 2020 · 5 citations
    13. Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin Journal of Investigative Dermatology · 2011 · 28 citations
    14. ILK modulates epithelial polarity and matrix formation in hair follicles Molecular biology of the cell · 2013 · 22 citations
    15. Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids Organoid · 2022 · 2 citations
    16. Transformation of amnion epithelium into skin and hair follicles Differentiation · 2004 · 33 citations
    17. Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse Gene Expression Patterns · 2006 · 17 citations
    18. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis Development · 2004 · 293 citations
    19. [Genetic expression and morphogenesis of the skin in vertebrates]. PubMed · 1993 · 5 citations
    20. Multifunctional Silk Fibroin Hydrogel with Antibacterial and Regenerative Properties for Accelerated Wound Healing Gels · 2026
    21. Hair Growth Cycle Affects Hair Follicle Destruction by Ruby Laser Pulses Journal of Investigative Dermatology · 1998 · 112 citations
    22. Thymosin β<sub>4</sub>increases hair growth by activation of hair follicle stem cells The FASEB Journal · 2003 · 98 citations
    23. Single follicular unit transplantation reconstructs arrector pili muscle and nerve connections and restores functional hair follicle piloerection The Journal of Dermatology · 2012 · 13 citations
    24. Hair follicle organoids: advances in construction, applications, and translational challenges Frontiers in Cell and Developmental Biology · 2026
    25. Hierarchical patterning modes orchestrate hair follicle morphogenesis PLoS Biology · 2017 · 149 citations
    26. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing Nature Communications · 2018 · 145 citations
    27. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles Differentiation · 1994 · 130 citations
    28. Epidermal stem cells and skin tissue engineering in hair follicle regeneration World Journal of Stem Cells · 2015 · 83 citations
    29. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin The FASEB Journal · 2003 · 81 citations
    30. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012 · 65 citations