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    Glossary Gonadotropin-Releasing Hormone Antagonists

    medications that block hormone signals to reduce sex hormone production

    Gonadotropin-Releasing Hormone Antagonists (GnRH antagonists) are medications that block the action of GnRH, a hormone responsible for stimulating the release of other hormones like LH and FSH from the pituitary gland. By inhibiting this pathway, GnRH antagonists can reduce the production of sex hormones such as testosterone and estrogen, making them useful in treatments for conditions like prostate cancer, endometriosis, and certain fertility issues.

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    1. Polycystic ovary syndrome and infertility: an update International journal of adolescent medicine and health · 2021 · 26 citations
    2. Pharmacological Control of Reproduction in the Dog and Cat 2019
    3. Hormone therapy in acne Indian Journal of Dermatology, Venereology and Leprology · 2013 · 24 citations
    4. Corticotropin releasing factor-1 receptor antagonism associated with favorable outcomes of male reproductive health biochemical parameters Frontiers in Endocrinology · 2023
    5. Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male Urologic Clinics of North America · 2016 · 70 citations
    6. ANTIANDROGEN THERAPY IN DERMATOLOGY International Journal of Dermatology · 1996 · 32 citations
    7. CLINICAL UPDATES IN HAIR Dermatologic Clinics · 1997 · 19 citations
    8. Novel anti-Mullerian hormone receptor 2 binding peptide prevents chemotherapy-related ovarian follicle loss in a mouse model Journal of Assisted Reproduction and Genetics · 2026
    9. Reporting on Adverse Clinical Events Clin-Alert · 2010
    10. Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism European Journal of Clinical Investigation · 2011 · 39 citations
    11. Characteristics of flutamide action on prostatic and testicular functions in the rat Journal of Steroid Biochemistry · 1988 · 30 citations
    12. Neuroendocrine Determinants of Polycystic Ovary Syndrome International Journal of Environmental Research and Public Health · 2022 · 19 citations
    13. Ovarian hyperthecosis in adolescent females: two case reports and a review of the literature Journal of Pediatric Endocrinology and Metabolism · 2024
    14. Impact of Medical Castration on Malignant Arrhythmias in Patients With Prostate Cancer Journal of the American Heart Association · 2021 · 8 citations
    15. Invasion and increased expression of S100A4 and CYR61 in mesenchymal transformed breast cancer cells is downregulated by GnRH International Journal of Oncology · 2016 · 21 citations
    16. Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes Women s Health · 2025 · 12 citations
    17. Microglia: sculptors of the polycystic ovary syndrome (PCOS)-like brain? Reproduction · 2023 · 1 citations
    18. Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies Experimental Dermatology · 2020 · 15 citations
    19. Redefining hormone resistance in prostate cancer Therapeutic Advances in Medical Oncology · 2009 · 38 citations
    20. Steroid Hormones Elsevier eBooks · 2016 · 3 citations
    21. Treatment of androgen excess in females: Yesterday, today and tomorrow Gynecological Endocrinology · 1997 · 9 citations
    22. Androgen Receptor Ligands: Agonists and Antagonists Elsevier eBooks · 2017 · 2 citations
    23. Hormonal Therapy for Acne Journal of Cutaneous Medicine and Surgery · 1996 · 1 citations
    24. Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities 2021 · 25 citations
    25. Follikelhormone Springer Reference Medizin · 2019
    26. Prostate-Sparing Effects in Primates of the Potent Androgen 7α-Methyl-19-Nortestosterone: A Potential Alternative to Testosterone for Androgen Replacement and Male Contraception1 The Journal of Clinical Endocrinology and Metabolism · 1998 · 14 citations
    27. Contaminants of emerging concern in the fetal environment 2022
    28. The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia Skin Pharmacology and Physiology · 2015 · 15 citations
    29. Phase 2, double-blind, randomized, placebo-controlled study of the safety and efficacy of elagolix in women with polycystic ovary syndrome F&S Reports · 2023 · 2 citations
    30. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024