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    Glossary Gonadotropin-Releasing Hormone Agonists

    medications that initially boost, then suppress, sex hormone production

    Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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    1. Clinical and Hormonal Effects of Chronic Gonadotropin Releasing Hormone Agonist Treatment in Polycystic Ovarian Disease* The Journal of Clinical Endocrinology & Metabolism · 1987 · 96 citations
    2. Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5<i>α</i>-Reductase Activity and Androgen Receptor Content* 1989 · 82 citations
    3. Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)∗ 1986 · 77 citations
    4. Comparison of a gonadotropin-releasing hormone agonist and a low dose oral contraceptive given alone or together in the treatment of hirsutism. The Journal of Clinical Endocrinology & Metabolism · 1995 · 62 citations
    5. Gonadotrophin-releasing hormone agonist therapy for hirsutism is as effective as high dose cyproterone acetate but results in a longer remission Human reproduction · 1997 · 49 citations
    6. Gonadotropin-Releasing Hormone Agonist Treatment in Postmenopausal Women with Hyperandrogenism of Ovarian Origin The Journal of Clinical Endocrinology & Metabolism · 2011 · 36 citations
    7. Gonadotropin releasing hormone agonist (nafarelin) test to differentiate gonadotropin deficiency from constitutionally delayed puberty in teen-age boys--a clinical research center study. 1995 · 24 citations
    8. Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor The Journal of Clinical Endocrinology & Metabolism · 1997 · 19 citations
    9. Treatment of hirsutism with a gonadotropin-releasing hormone agonist and estrogen replacement therapy Fertility and sterility · 1994 · 19 citations
    10. A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism. PubMed · 2000 · 10 citations
    11. Sequential estrogen-progestin addition to gonadotropin-releasing hormone agonist suppression for the chronic treatment of ovarian hyperandrogenism: a pilot study. 1994 · 2 citations
    12. (PNM-35) Recurrent priapism in a sickle cell disease patient treated with gonadotropin-releasing hormone (GnRH) agonists drugs: a case report The Journal of Sexual Medicine · 2026
    13. DIAGNOSTIC AND THERAPEUTIC UTILITY OF GONADOTROPHIN-RELEASING HORMONE AGONIST IN POSTMENOPAUSAL HYPERANDROGENISM OF OVARIAN ORIGIN Journal of the ASEAN Federation of Endocrine Societies · 2023
    14. Differential Suppression of Testosterone and Estradiol in Hirsute Women With the Superactive Gonadotropin-Releasing Hormone Agonist Leuprolide* The Journal of Clinical Endocrinology & Metabolism · 1988 · 49 citations
    15. Hormone therapy in acne Indian Journal of Dermatology, Venereology and Leprology · 2013 · 24 citations
    16. Novel anti-Mullerian hormone receptor 2 binding peptide prevents chemotherapy-related ovarian follicle loss in a mouse model Journal of Assisted Reproduction and Genetics · 2026
    17. Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone Journal of Clinical & Translational Endocrinology · 2024 · 1 citations
    18. 17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Disclose Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2007 · 42 citations
    19. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2017 · 2170 citations
    20. Physical Changes, Laboratory Parameters, and Bone Mineral Density During Testosterone Treatment in Adolescents with Gender Dysphoria ˜The œjournal of sexual medicine · 2019 · 71 citations
    21. Hormonal treatment of acne vulgaris: an update Clinical, Cosmetic and Investigational Dermatology · 2016 · 46 citations
    22. ANTIANDROGEN THERAPY IN DERMATOLOGY International Journal of Dermatology · 1996 · 32 citations
    23. 9 Diagnosis and therapy of hyperandrogenism Baillière's clinical obstetrics and gynaecology · 1997 · 23 citations
    24. CLINICAL UPDATES IN HAIR Dermatologic Clinics · 1997 · 19 citations
    25. Medical Treatment of Hirsutism in Women Current medicinal chemistry · 2010 · 18 citations
    26. Hirsutes II: Treatment Australasian journal of dermatology · 1998 · 15 citations
    27. Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes Women s Health · 2025 · 12 citations
    28. The Polycystic Ovary Syndrome and Acne Springer eBooks · 2014 · 2 citations
    29. Hirsutism Obstetrics, gynaecology and reproductive medicine · 2012 · 2 citations
    30. Postmenopausal Hyperandrogenism in a Patient With an Adrenal Adenoma: How Should We Approach It? AACE clinical case reports · 2015 · 1 citations