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The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Forehead modification greatly increases the perception of femininity and is a safe procedure.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Female hair loss linked to metabolic syndrome, not in males.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

The conclusion is that certain surgeries can help people with gender dysphoria look more like their true gender and feel better.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Most insurance companies do not cover extra gender-affirming surgeries, with coverage being low and inconsistent.

Younger transgender women have surgery earlier, are mostly attracted to men, and show more preoperative depression that improves after surgery compared to older transgender women.

Women's hair grows faster and thicker than men's, but hair growth slows for both genders with pattern hair loss.

Transgender youth have more sleep disorders, but gender-affirming therapy may help reduce them.

Men and premenopausal women in Korea show different patterns in iron and vitamin D levels, with no clear pattern for postmenopausal women.

Gender differences affect allergy prevalence, severity, and response to environmental toxins, with women often more affected than men.

Gender-affirming care for youth remained essential during the COVID-19 pandemic, with telemedicine playing a key role.

AGA treatments like minoxidil and LLLLT are safe and effective for gender minority patients.

Women pay more for the same 5% minoxidil foam than men, but prices for liquid solutions are similar.

Men are more likely to have larger basal cell carcinomas and squamous cell carcinomas, while women have more superficial basal cell carcinomas and tumors on their legs and central face.

Gendered social factors, not just biology, contribute to sex differences in adverse drug events.

Transgender and nonbinary individuals experience hair loss, with transmen on testosterone seeing more severe hair loss, while feminizing hormones may stabilize hair loss in transwomen.

AGA risk factors include age, smoking, hypertension for men, and age, dyslipidemia for women; lifestyle changes may help prevention.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.