Gender Difference in Relationship Between Serum Ferritin and 25-Hydroxyvitamin D in Korean Adults

The study analyzed the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] levels in 5,147 Korean adults, revealing gender-specific associations. In men, an inverse relationship was found, with higher 25(OH)D levels correlating with lower serum ferritin levels (P = 0.012). Premenopausal women showed a positive association, where increased serum 25(OH)D levels were linked to higher serum ferritin levels (P = 0.003). However, no significant association was observed in postmenopausal women (P = 0.456). The study concluded that the relationship between serum ferritin and 25(OH)D levels varies by gender and menopausal status, with distinct patterns observed in men and premenopausal women, and no significant pattern in postmenopausal women.