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Both Th1 and Th2 immune responses are increased in alopecia areata, with Th2 response more strongly linked to how severe the disease is.

Activating Nrf2 helps wounds heal faster by increasing hair follicle stem cells.

Desmoglein 3 organization in cell connections changes without calcium, affecting cell adhesion.

Dsg1 is essential for maintaining a healthy skin barrier in mice.

Topical tofacitinib is effective in promoting hair growth for non-scarring alopecia.

Nonmelanoma skin cancers have higher levels of certain osteopontin variants than normal skin.

Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.

Anti-glycation treatments might slow skin aging, but more research is needed.

Sleep problems and skin issues affect each other; poor sleep can worsen skin conditions, and some skin treatments can improve or harm sleep quality.

The document concludes that severe trauma can cause temporary hair loss, known as Telogen Effluvium, which usually resolves without treatment.

Adult hair follicle cells can create new hair follicles from corneal cells with the right support.

Docetaxel is safe and works well for older people with cancer, with manageable side effects.

Parthenolide promotes hair growth in mice and may influence pathways related to male pattern baldness.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Finasteride and dutasteride, used for prostate issues and hair loss, can cause side effects like sexual dysfunction and mental issues, which may continue even after stopping the medication, a condition called post-finasteride syndrome, for which there's currently no cure.

Hair loss can cause significant social and emotional issues, especially for women and young men.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.