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Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Polymeric nanoparticles show promise for treating skin diseases.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Androgens can both increase and decrease hair growth in different parts of the body.

Targeted cancer therapies often cause serious skin problems that need careful management.

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

RANK-RANKL signaling is essential for hair growth and skin health.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

Improving the environment and cell interactions is key for creating human hair in the lab.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Older skin has higher cancer risk due to inflammation and stem cell issues.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

Antidepressants called SSRIs can cause skin problems, bleeding risk, and other side effects.