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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.

Australian doctors experienced in adult transgender healthcare mostly prescribe intramuscular testosterone and oral estradiol, recommend mental health assessments before hormone therapy, and support improved training and guidelines.

Many children and teens referred to gender services receive hormone treatments, but more research is needed on their long-term care and outcomes.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

Hormone therapy may increase migraines in transgender women and decrease them in transgender men; more research is needed on migraine management in transgender individuals.

Transgender patients in critical care need better-trained medical staff and specific guidelines.

The document concludes that respectful, gender-affirming healthcare improves mental health and encourages continued medical care for transgender and non-binary individuals.

Dermatologists are essential in helping transgender and gender diverse patients with skin and hair issues related to gender affirmation and hormone therapy.

Heat and chemicals improve finasteride delivery to scalp and hair follicles, potentially enhancing treatment for hair loss.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

Eflornithine's effectiveness for women with facial hirsutism is unclear.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

The document concludes that treatments for female hair loss and excessive hair growth are temporary and not well-studied.

Women with congenital adrenal hyperplasia (CAH) have more sexual function issues than those with polycystic ovary syndrome (PCOS), but physical activity can improve sexual functioning in all women.

The document concludes that management strategies for PCOS are important due to its common occurrence and associated health risks.

Addressing underrepresentation in Parkinson's research is crucial for better treatments and understanding.

Air Vice-Marshal Sir Ralph Jackson significantly advanced dialysis technology in the UK.

Uterine transplants for transgender women are feasible but need more research.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.

Cyproterone acetate is a safe treatment that causes mild feminizing effects and is more effective with added estrogens.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Cyproterone acetate is a safe treatment that causes modest feminization in transgender female adolescents, and works better with added estrogens.

Finasteride and minoxidil together promote hair growth better than either alone.