TLDR Uterine transplants for transgender women are feasible but need more research.
The document discussed the feasibility and ethical considerations of uterine transplantation (UTx) in male-to-female (M2F) transgender women. It highlighted that UTx had been successful in women with absolute uterine factor infertility (AUFI), with over 42 procedures and at least 12 live births globally. Ethical motivations included justice and equality, as transgender women also experience AUFI and could benefit psychologically from gestation. Anatomical and physiological challenges were noted, such as differences in pelvic vascular anatomy and the need for a functioning vaginal mucosa. Potential solutions included utero-vaginal transplants from deceased donors or female-to-male (F2M) transgender men. Hormonal management and fertility considerations were also addressed, emphasizing tailored hormone replacement therapy and careful planning of embryo transfers. Despite challenges, there was no strong clinical argument against UTx in transgender women, and further research was recommended to assess feasibility and risks.
83 citations,
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