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Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.

Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.

Eating selenium-rich rice improved antioxidant activity and signs of aging in mice.

HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.

Tissue-derived extracellular vesicles are crucial for cancer diagnosis, prognosis, and treatment.

High-fructose diets can cause irreversible kidney damage.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Human hair follicles can make and process prostaglandins, which may affect hair growth.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.