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The same genetic mutation in Sjögren-Larsson syndrome can lead to different levels of severity, suggesting other factors influence the symptoms.

Patients with RASopathies are at risk for autoimmune disorders and should be routinely screened.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

Injecting a person's own fat stem cells into their skin can make it look younger and improve double eyelids for over a year.

Countries with stricter cultures had fewer COVID-19 cases and deaths, paranoia is linked to false memories, psychosocial intervention works as well with or without antipsychotic drugs for young people with psychosis, smartphones can detect changes in behavior indicating illness relapse, and recruitment agents show regional and gender biases.

Metformin improves quality of life, emotional health, and sex life in women with polycystic ovary syndrome.

Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.

Mycophenolate mofetil may improve lupus nephritis remission more than cyclophosphamide but with uncertain safety.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.

Testosterone is linked to cardiovascular risk factors and stroke, but its exact role is unclear.

Testosterone's effects on COVID-19 are unclear and need more research.

Thiopurines help treat IBD but require genetic testing to avoid side effects.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

There is a significant need for better-validated quality of life tools in dermatology.

Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.

Natural products like coconut oil and aloe vera are beneficial in cosmetics for their healing properties.

Certain skin conditions in women are linked to higher risks of metabolic syndrome and type 2 diabetes due to hormone imbalances.

Polycystic ovary syndrome increases the risk of diabetes, heart disease, and endometrial cancer, and requires early treatment to manage these risks.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

Androgen deprivation therapy doesn't lower the risk of death from COVID-19 in prostate cancer patients.

Gendered social factors, not just biology, contribute to sex differences in adverse drug events.

Diagnosing and treating PCOS in teenagers is difficult, and the focus is on lifestyle changes and medication to improve health and prevent future issues.

Older, obese people with many COVID-19 symptoms are more likely to suffer from severe long-term COVID-19 effects.

Women with PCOS may have higher bad cholesterol and are at risk for blood sugar issues; lifestyle changes are recommended.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

The 2018 guideline for PCOS suggests new diagnostic criteria and treatments, but recognizes the need for more research.

Aesthetic medicine needs clear ethical guidelines to ensure patient well-being and safety.