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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

Dermatologists are essential in helping transgender and gender diverse patients with skin and hair issues related to gender affirmation and hormone therapy.

Use minoxidil for hair loss treatment; assess results after 6 months.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Some hormone treatments might raise breast cancer risk, while others don't seem to.

Eating a balanced diet with specific nutrients can help manage menopause symptoms and prevent related health issues.

The document concludes that various cosmetic and drug treatments are available for hirsutism, and some new drugs show promise.

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

Excessive hair growth in women can be harmless or signal serious health issues, and treatment often includes medication and hair removal, with noticeable results after 3-6 months.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

Adalimumab is the most effective treatment for severe hidradenitis suppurativa, but more research is needed to improve treatment options.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.

Oxidative stress is higher in women with PCOS, especially if they're obese, and it may increase their risk of heart disease.

Hormones might affect the skin condition hidradenitis suppurativa, but their exact role is unclear.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

PCOS affects nearly 25% of female medical and dental students, impacting their academic and social lives.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.