53 citations
,
May 1995 in “Journal of The American Academy of Dermatology” This article describes two cases where essential alopecia was the initial sign of syphilitic infection, examining the clinical and histopathologic features observed.
10 citations
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July 2012 in “International Journal of Dermatology” This article addresses diffuse pattern essential syphilitic alopecia as an unusual form of secondary syphilis but provides no new clinical findings.
January 2021 in “Our Dermatology Online” This case report discusses alopecia syphilitica in a young Belgian man, notes that hair loss was his only symptom, and highlights the improvement following penicillin treatment.
3 citations
,
July 2014 in “QJM” This case report discusses a 35-year-old man with progressive alopecia areata who did not respond to minoxidil treatment but offers no new clinical trial results.
1 citations
,
July 2025 in “Dermatology Reports” This case report highlights a rare instance of syphilitic alopecia and ocular syphilis in an immunocompetent, HIV-negative woman, showing that syphilis-directed treatment led to symptom reversal, emphasizing the need to consider syphilis in the differential diagnosis for atypical alopecia.
3 citations
,
January 2015 in “Dermatology Online Journal” This case report highlights a patient whose essential syphilitic alopecia was the only symptom of syphilis, which improved after benzathine penicillin treatment, emphasizing alopecia as a potential sign of syphilis.
32 citations
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July 2017 in “Dermatology practical & conceptual” This study is the first to describe a mixed pattern of essential syphilitic alopecia using trichoscopy, identifying features like tapered bended hairs and perifollicular hyperkeratosis in a patient without secondary syphilis symptoms.
1 citations
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January 2021 in “Nihon rinsho hifukaikai zasshi” This article discusses the diagnostic methods for differentiating alopecia areata from similar hair loss conditions and emphasizes the importance of accurate diagnosis, but it reports no new research findings.
April 2026 in “Frontiers in Medicine” This case study reports a 26-year-old male with secondary syphilitic alopecia misdiagnosed as alopecia areata, likely contracted through non-penetrative sexual contact. Effective treatment with intramuscular benzathine penicillin G led to complete hair regrowth within three months.
April 2012 in “Informa Healthcare eBooks” Syphilitic alopecia is a rare hair loss condition in secondary syphilis that looks similar to another condition but can be diagnosed with specific tests and responds to antibiotics.
29 citations
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January 2017 in “Skin appendage disorders” This case study highlights the importance of considering syphilis in the differential diagnosis for hair loss, as patients with the infection may present with non-typical alopecia patterns.
11 citations
,
May 2020 in “Anais Brasileiros de Dermatologia” This case report describes a patient with secondary syphilis exhibiting distinct dermoscopic features, including moth-eaten alopecia and an erythematous background more pronounced than previously reported.
13 citations
,
June 2013 in “Actas Dermo-Sifiliográficas” This review details five cases of syphilitic alopecia, an uncommon symptom in syphilis affecting mainly men, emphasizing that dermatologists should be vigilant as it can appear as the sole symptom.
4 citations
,
May 2022 in “Frontiers in Medicine” The authors concluded that trichoscopic examination can be useful for diagnosing syphilitic alopecia in patients with idiopathic alopecia, though the findings are nonspecific and further studies are needed.
1 citations
,
July 2024 in “Indian Journal of Sexually Transmitted Diseases and AIDS” In this study, a 38-year-old male with syphilis-related mixed pattern alopecia showed marked hair regrowth and resolution of postauricular lymphadenopathy after treatment with benzathine penicillin, suggesting that lymph node and hair examinations, along with trichoscopy, can aid in the diagnosis of alopecia syphilitica.
November 2012 in “South African Family Practice” This article describes the phases of the hair cycle in detail but reports no new clinical findings or results related to alopecia.
July 2012 in “Springer eBooks” The document concludes that proper diagnosis and treatment of nonscarring alopecias can improve quality of life and hair regrowth is possible as the hair follicle remains intact.
1 citations
,
August 2023 in “Clinical Cosmetic and Investigational Dermatology” This study found that exclamation mark hairs are the only trichoscopic feature that can differentiate clinically suspicious SA from AA.
122 citations
,
April 1995 in “Journal of Cutaneous Pathology” The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
13 citations
,
February 2015 in “Actas Dermo-Sifiliográficas” This review discusses the histologic features of nonscarring alopecia and highlights the importance of clinical-pathological correlation for accurate diagnosis, but reports no new clinical results.
1 citations
,
January 2016 in “Case Reports in Clinical Medicine” This case report describes a 46-year-old Japanese man with syphilitic alopecia and HIV who showed rapid improvement and hair regrowth after taking ampicillin.
February 2026 in “Cureus” This case report highlights that alopecia areata can mimic syphilitic alopecia in patients with recent or active syphilis, emphasizing the importance of trichoscopy in accurately diagnosing alopecia types and preventing misdiagnosis.
December 2020 in “Journal of clinical and investigative dermatology” This case study highlights the rare simultaneous presentation of syphilitic alopecia and neurosyphilis in a 61-year-old man, underscoring the importance of recognizing this combination for timely treatment.
64 citations
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July 1997 in “Journal of The American Academy of Dermatology” This study found that eosinophils are a useful diagnostic feature for alopecia areata, especially when the typical "swarm of bees" lymphoid infiltrate is absent, helping differentiate it from trichotillomania.
21 citations
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March 2006 in “Seminars in Cutaneous Medicine and Surgery” This review discusses a clinical approach to diagnosing alopecia through patient history and clinical findings, but it reports no new clinical results.
7 citations
,
July 2019 in “Clinics in Dermatology” This review discusses various systemic diseases associated with secondary alopecia and reports no new clinical findings; it emphasizes the importance of addressing underlying conditions and using diagnostic tools like trichoscopy and histopathology.
45 citations
,
January 2015 in “Dermatology” In this study, 41.6% of patients with secondary syphilis exhibited syphilitic alopecia, with the 'moth-eaten' pattern most commonly observed through trichoscopy.
2 citations
,
December 2012 in “Acta Facultatis Medicae Naissensis” This article presents a case of syphilitic alopecia in a man, where treatment with benzathine penicillin G led to dramatic hair regrowth and resolution of syphilitic lesions within three months.
October 2025 in “Journal of Advanced Trends in Medical Research” This review highlights the potential of rosemary as a treatment for various types of alopecia, with effects possibly comparable to minoxidil and a favorable safety profile, though further large-scale studies are necessary to confirm these findings.
3 citations
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July 2012 in “British journal of hospital medicine” This article reviews common hair loss disorders, emphasizing their potential links to systemic disease and the importance of thorough diagnostic evaluation, but reports no new clinical results.