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    Glossary Dermal-Epidermal Junction

    interface where the epidermis connects to the dermis

    The Dermal-Epidermal Junction (DEJ) is a critical area of skin where the outer layer (epidermis) connects to the underlying layer (dermis). This junction plays a vital role in maintaining skin integrity, facilitating nutrient exchange, and supporting cellular communication. It is essential for wound healing and overall skin health, and its degradation can lead to various skin disorders.

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    1. Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids Stem cell reports · 2022 · 14 citations
    2. Novel approaches to characterize age‐related remodelling of the dermal‐epidermal junction in 2D, 3D and <i>in vivo</i> Skin research and technology · 2016 · 30 citations
    3. 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast Journal of Investigative Dermatology · 2018
    4. The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form Anchoring Cords in the Absence of AMACO at the Dermal–Epidermal Junction of Mouse Skin International journal of molecular sciences · 2023 · 1 citations
    5. 565 hiPSC-derived skin organoids as tools for disease modelling: characterization of the epidermal-dermal junction Journal of Investigative Dermatology · 2022
    6. 918 Skin morphogenesis by coupling biochemical-bioelectric signals: Calcium oscillations coordinate dermal cell movement by epidermis-derived SHH signaling during feather bud orientation Journal of Investigative Dermatology · 2019
    7. Expression of laminin, type IV collagen and fibronectin molecules is related to embryonal skin and epidermal appendage morphogenesis. PubMed · 2001 · 10 citations
    8. 0873 Modeling junctional epidermolysis bullosa using tissue-engineered skin substitutes Journal of Investigative Dermatology · 2025
    9. Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue npj regenerative medicine · 2023 · 6 citations
    10. Inducible cre-mediated N-ras activation and PTEN inactivation in transgenic mouse melanocytes requires keratinocyte hyperplasia to elicit a melanocyte pathology Enlighten: Publications (The University of Glasgow) · 2005
    11. Distribution of P2X<sub>3</sub>‐immunoreactive fibers in hairy and glabrous skin of the rat Journal of comparative neurology · 2009 · 41 citations
    12. Quantitative morphometric analysis of intrinsic and extrinsic skin ageing in individuals with Fitzpatrick skin types II–III Experimental dermatology · 2023 · 4 citations
    13. Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors Nature Communications · 2014 · 66 citations
    14. Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle. PubMed · 1992 · 45 citations
    15. Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells Journal of Dermatological Science · 2024 · 1 citations
    16. Collagen XVIIα1 in skin and hair aging: Mechanisms, stem cell niche regulation, and translational strategies Journal of Dermatological Science · 2026
    17. SnapshotDx Quiz: May 2020 2020
    18. Sclero-Atrophic Reaction after Botulinum Toxin Injection Journal of Clinical Research in Dermatology · 2016
    19. Distribution of Type XII and XIV Collagens in Bovine Dermis and Hair Follicles Connective tissue · 2001
    20. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    21. Ultrastructural Study on Connective Tissue-Epithelial Junctions in Anagen Hair Follicle of Human Fetus 1997
    22. Lentinula edodes (Shiitake) extract as a vitamin D receptor activator to enhance skin adaptogenic responses Scientific Reports · 2026
    23. Immunofluorescence analysis of the basement membrane zone components in human anagen hair follicles Experimental Dermatology · 2003 · 29 citations
    24. TERMIS ‐ AMERICAS Toronto, Ontario, Canada July 10–13, 2022 Tissue Engineering Part A · 2022
    25. 3D organotypic skin models recapitulate autoantibody-driven pemphigus pathomechanisms and targeted therapeutic response Science Advances · 2026 · 1 citations
    26. Histological study of white rhinoceros integument PLoS ONE · 2017 · 10 citations
    27. Petechiae on the fingertips as presenting symptom of dermatitis herpetiformis Duhring Journal of the European Academy of Dermatology and Venereology · 2009 · 30 citations
    28. Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment Stem Cell Reviews and Reports · 2021 · 6 citations
    29. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    30. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008 · 41 citations