Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This article reviews the genetic foundations of keratins in maintaining epithelial tissue integrity and links specific keratin variants to diverse ichthyosis forms, without presenting new clinical findings.

This study presents evidence that keratitis–ichthyosis–deafness syndrome is caused by a mutation in the connexin 26 gene, expanding the gene's known involvement in various disorders.

CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.

In this case report, a 39-year-old woman's symptoms from dermatomyositis–systemic lupus erythematosus overlap syndrome improved only after she was treated with tofacitinib.

This article presents four case reports of men with porphyria cutanea tarda and hepatitis C, highlighting associations with polysubstance abuse, primarily alcohol.

This case report suggests that topical tacrolimus may effectively manage erosive pustular dermatosis of the scalp and reverse skin atrophy, although long-term use requires monitoring for side effects.

This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.

This review discusses the role of Edar signaling in hair follicle development and cycling, emphasizing its impact on cell fate, differentiation, and interactions with other pathways, but reports no new results.

This study demonstrated that acute thallium poisoning primarily manifests with gastrointestinal issues, polyneuropathy, and dermatological changes, and treatments like hemoperfusion and hemodialysis may improve symptoms.

This study found that the restoration of CD103⁺γδ T cells in humans is associated with sustained remission in inflammatory bowel disease, suggesting a conserved role for these cells in limiting disease progression.

This paper reviews total skin electron therapy for mycosis fungoides and reports no new results; the authors focus on dose de-escalation's impact on toxicity and response rates.

Ritlecitinib may help treat alopecia areata by protecting hair follicles.

This case study describes a 7-month-old boy diagnosed with keratitis-ichthyosis-deafness syndrome due to a de novo GJB2 gene mutation, highlighting the challenges in treatment and eventual fatal outcome due to severe complications.

This study found that dracorhodin perchlorate improved wound healing in diabetic rats by regulating the TLR4 pathway and related inflammatory factors.

This case report describes the management of PRIDE complex, a skin and hair condition associated with EGFR inhibitor treatment like cetuximab, emphasizing that it does not require stopping the medication.

This case report describes a 16-year-old with ectrodactyly-ED-clefting syndrome, where scarring alopecia with follicular involvement appeared during puberty, possibly due to anatomic hair abnormalities.

This study found that high-flux hemodialysis combined with L-carnitine improved heart function, reduced inflammation, and decreased venous fistula complications in maintenance hemodialysis patients.

This study reports that teflonpledget-reinforced suturing of coronary fistula, combined with coronary artery bypass grafting, improved symptoms in patients with LAD-to-MPA fistula and triple vessel disease, though larger studies are needed for confirmation.

This study found that blocking the hypothalamic-pituitary-gonadal axis in male rats reduced baroreflex dysfunction and inflammation caused by endotoxemia, highlighting potential therapeutic benefits.

In this study, researchers analyzed skin tumors from patients with CYLD cutaneous syndrome and found that loss of CYLD function is linked to changes in cellular signaling pathways, particularly NF-κB signaling, and leads to increased secretion of specific extracellular matrix proteins.

This study found that epitestosterone acts as a weak antiandrogen by inhibiting receptor binding and 5α-reductase activity in animal models.

This study found that thalidomide increased peripheral lymphocyte counts and reduced inflammation in lupus erythematosus patients, but was associated with polyneuropathy, suggesting careful use in refractory cases.

The document discusses a special exam case for formulating and using systemic therapy named Athena.

This review discusses therapeutic deep eutectic solvents as promising "green" solutions for enhancing drug solubility and delivery through the skin, reporting no new clinical results and highlighting future research directions.

In laboratory tests and mouse models, this study found that the novel IPC analog SIG-1451 may offer potent anti-inflammatory effects for treating allergic skin inflammation, potentially outperforming some current therapies in specific inflammatory phases.

In this case report, an 11-year-old girl with acrodermatitis enteropathica experienced a complete resolution of symptoms following oral zinc therapy, highlighting its effectiveness in managing this condition.

This study found that eribulin-based chemotherapy resulted in longer median progression-free and overall survival, with fewer side effects, for advanced triple-negative breast cancer patients compared to other chemotherapy options.

In this study, Tithonia diversifolia extract was found to improve certain digestive parameters in crossbred sheep but did not enhance growth performance, as the improvements in digestion did not translate into increased body weight or feed conversion.

This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.