Scalp-Sparing Total Skin Electron Therapy in Mycosis Fungoides: Case Report Highlighting Technique and Outcome

March 2016 in “ Practical radiation oncology ”

Noelle L. Williams, James Keller, E Kremmel, Virginia Lockamy, A Harrison, Wenyin Shi

scalp-sparing total skin electron therapy mycosis fungoides cutaneous T-cell lymphoma total skin electron therapy dry desquamation skin erythema alopecia anhidrosis TSET MF

TLDR Total skin electron therapy is an effective treatment for mycosis fungoides, balancing effectiveness and side effects.

The document discussed a case report on scalp-sparing total skin electron therapy (TSET) for treating mycosis fungoides (MF), the most common cutaneous T-cell lymphoma. Historically, TSET showed improved complete response rates with dose escalation from 8 Gy to 36 Gy, but this also increased toxicity, including dry desquamation, skin erythema, alopecia, anhidrosis, and loss of fingernails. Recent studies have focused on dose de-escalation to reduce these toxicities while maintaining response rates. The case report highlighted the technique and outcomes of using a scalp-sparing approach in TSET.

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