research Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches
Drug repositioning is a promising way to quickly develop new treatments, especially for rare diseases.
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research Network-Based Drug Repositioning: Approaches, Resources, and Research Directions
The document concludes that computational methods using networks and various data can improve the process of finding new uses for existing drugs.
research Repurposing of Approved Cardiovascular Drugs
Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.
research Can We Teach Old Drugs New Tricks? Repurposing Neuropharmacological Drugs for Inflammatory Skin Diseases
Old neuropharmacological drugs might be effective for treating inflammatory skin diseases.
research Repurposing of Drugs as Novel Influenza Inhibitors from Clinical Gene Expression Infection Signatures
Existing drugs, including a blood pressure medication, show promise as new treatments for influenza.
research Identification of Drug-Disease Associations Using Information of Molecular Structures and Clinical Symptoms via Deep Convolutional Neural Network
A new model can predict drug-disease links well, helping drug research.
research Medication Repurposing: New Uses for Old Drugs
Old drugs can be used for new treatments, saving time and money, but there are challenges like needing more evidence and legal concerns.
research Repurposing of H1-Receptor Antagonists Cetirizine, Loratadine, and Fexofenadine for Systematic Analysis of ClinicalTrials.gov Trials Using Semi-Automated Processes
Custom software found that common allergy drugs might have new uses for various conditions and could improve survival in some cancers.
research Advances in the Treatment of Autosomal Recessive Congenital Ichthyosis: A Look Towards the Repositioning of Drugs
Drug repositioning offers hope for new, affordable treatments for a genetic skin disorder called ARCI.
research Evaluation of Contamination and Quantification of Drug Penetration Studies Using Quantitative Mass Spectrometry Imaging
QMSI is a valuable method for studying drug penetration in skin tissues.
research Nanospanlastic as a Promising Nanovesicle for Drug Delivery
Nanospanlastics are effective in targeted drug delivery for chronic diseases, improving skin conditions, treating hair loss, and increasing drug absorption.
research Efficacy of Topical Vorinostat in the Reversal of Alopecia Areata
Topical Vorinostat shows promise for treating alopecia areata by promoting hair regrowth.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
Reviewers criticized the study for assuming drugs with similar side-effects work the same way and questioned the validity of its findings due to potential biases and data quality issues.
research Drug Repositioning Using In Silico Compound Profiling
Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.
research Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing
Researchers identified five new potential targets for leishmaniasis treatment, suggesting repurposing existing drugs could be effective.
research The Pattern of Off-Label and Unlicensed Drug Use in Adult and Pediatric Patients in the Kingdom of Saudi Arabia: Multicenter Retrospective Study
Most off-label drug prescriptions in Saudi Arabia are for adults with depression and diabetes.
research Repurposing Steroidogenesis Inhibitors for the Therapy of Neuropsychiatric Disorders: Promises and Caveats
Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
research Therapeutics for COVID-19 and Post COVID-19 Complications: An Update
New treatments for COVID-19 show promise, but more effective antiviral drugs are needed.
research The Need for Speed and Efficiency: A Brief Review of Small Molecule Antivirals for COVID-19
Some small molecule antivirals show promise against COVID-19, but more research is needed to understand and improve them.
research Formulating, Optimizing, and Evaluation of Dutasteride Loaded In-Situ Emulgel for Androgenetic Alopecia
The new gel for hair loss is safe, effective, and reduces side effects.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
Reviewers criticized the study's methods and suggested focusing on drug mechanisms instead of repositioning due to social media data quality concerns.
research Predictive Modeling of Patient Response to JAK/STAT Inhibitors and Dynamic Patient-Matching
Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
Reviewers suggested the study on finding new drug uses through social media side-effects needs better methods and clearer limitations.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
The peer review highlighted the need for clearer data handling, questioned the study's validity, and recognized improvements from the original version.
research Efficacy of CD101, a Novel Echinocandin, in the Treatment of Dermatophytosis Using a Guinea Pig Model
CD101 is highly effective in treating dermatophytosis in guinea pigs.
research Promotion of Hair Growth in Alopecia Areata by Topical Treatment of HDAC Inhibitors
HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.
research High-Content Drug Screening for Rare Diseases
High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
Reviewers criticized the study for its assumptions, social media data collection issues, and lack of comparison to existing methods.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
The study improved and was accepted despite initial concerns about data clarity, methodology, and potential overfitting.
research Entrepreneurship in Off-Label Drug Prescription: Just What the Doctor Ordered!
The conclusion is that off-label drug use can lead to important medical discoveries and improve patient care.