January 1998 in “Proceedings of the British Society of Animal Science” This study investigated the effects of biotin deficiency and adequacy on cell proliferation and DNA synthesis in isolated mohair follicles, particularly focusing on the incorporation of [methyl-3 H]thymidine.
3 citations
,
November 2011 in “European Journal of Dermatology” This article discusses alopecia and the impact of hair loss on mental health, but it presents no new research findings and highlights the need for further studies.
5 citations
,
January 2013 in “Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery” This study found that a polyherbal formulation of Trigonella foenum-graecum and Butea monosperma significantly promoted hair growth and reduced DHT levels in a chemotherapy-induced alopecia model.
December 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This article discusses three herbal plants commonly used for hair growth support and reports no new clinical results; the authors suggest these herbs may help restore hair health.
This study found that the FER/MLO signaling module plays a crucial role in calcium oscillations and ROS production in root hair tip growth, with the MLO15 protein regulating these processes and restoring disrupted growth and signaling in fer mutant root hairs.
November 2022 in “Journal of Investigative Dermatology” This study found that autologous γdTregs displayed significant protective effects on alopecia areata-affected human scalp hair follicles in both ex vivo and in vivo settings, suggesting potential for future cell-based therapy.
September 2016 in “Journal of Dermatological Science” This study found that plasmacytoid dendritic cells may initiate alopecia areata in mice by overexpressing interferon-alpha.
January 2026 in “Frontiers in Pharmacology” This review highlights the potential of wedelolactone from the plant Wedelia Chinensis, summarizing its reported pharmacological effects, including anti-inflammatory, antiviral, antibacterial, antitumor, anti-osteoporosis activities, and organ protection based on existing in vitro and in vivo research findings.
55 citations
,
February 1975 in “Journal of Cutaneous Pathology” This study observed that during the rat hair cycle, DNA synthesis in dermal cells peaks during a specific growth stage, suggesting a coordinated metabolic activity with potential implications for alopecia areata research.
February 2026 in “PubMed” This study reported that polysaccharides from Astragalus roots could promote hair regeneration and optimize drug delivery when combined in innovative microneedles, effectively improving hair growth in mice with androgenetic alopecia.
August 2025 in “Current Issues in Molecular Biology” This study demonstrated that Periplaneta americana extract significantly promoted hair regeneration in depilated mice by enhancing superoxide dismutase activity, upregulating vascular endothelial growth factor, modulating the FOXO/PI3K/AKT pathway, and restoring skin microbiome balance, suggesting its potential as a novel therapeutic candidate for alopecia.
6 citations
,
April 1993 in “Journal of Dermatological Science” This study found that several anti-cancer agents strongly inhibit DNA synthesis in human hair germinative cells, while certain cytokines showed only slight inhibition.
July 2005 in “HortScience” This study found that adding sheep wool-waste or human hair-waste to soil increased yields and secondary metabolites in various crops and supported up to five harvests without additional fertilizers, though it decreased mycorrhizae colonization.
54 citations
,
June 1985 in “American Journal of Dermatopathology” This abstract does not provide specific findings or results.
November 2021 in “Journal of Regenerative Biology and Medicine” This article discusses alopecia areata, an inflammatory hair loss condition with largely unexplored causes, but provides no new research findings.
October 2021 in “Journal of Investigative Dermatology” In this study, researchers found that using a novel Leontopodium alpinum (Edelweiss) extract led to increased hair density and prolonged anagen phase in both ex vivo human hair follicles and a 5-month clinical trial, suggesting potential as an anti-hair loss treatment.
3 citations
,
January 1982 in “Australian journal of biological sciences” This study found that ethionine significantly inhibited wool growth in sheep, with L- and D-isomers being equally effective, but did not cause hair loss in sucking mice or rats.
February 2025 in “Applied Sciences” This study found that extracts from heterotropic cultures of Scenedesmus deserticola JD052 enhanced hair-inductive properties in human dermal papilla cells more effectively than photoautotrophic extracts, likely through activation of AKT/β-catenin signaling, despite similar loliolide content.
May 2026 in “BMC Medicine” This study found that ACOD1 deficiency in dermal papilla cells promotes mitochondrial dysfunction and contributes to cellular senescence in androgenetic alopecia, suggesting ACOD1 as a potential therapeutic target and 4-octyl itaconate as a promising treatment option for AGA.
February 2023 in “Current Pharmaceutical Design” This review explores medicinal plants as potential treatments for hair loss, suggesting their promise due to anti-inflammatory and antioxidant properties, but reports no new clinical results.
6 citations
,
June 1981 in “PubMed” This article reviews previously reported cases of whisker hair in individuals who develop severe androgenic alopecia and offers a hypothesis concerning its eventual fate, without presenting new findings.
30 citations
,
June 2015 in “South African journal of botany” This study documented 70 plant species used by traditional healers in Namibia to manage AIDS-related opportunistic diseases and highlighted the need for further research on their anti-HIV properties and potential over-exploitation.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review assesses the potential of ginger, garlic, onion, and clove as complementary herbal treatments for hair and scalp health, reporting that onion juice shows the strongest clinical evidence for hair regrowth, particularly in alopecia areata, while garlic exhibits promising preclinical regenerative effects.
23 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that topical minoxidil and diazoxide induced significant hair regrowth in bald macaques, while a steroid 5 alpha-reductase inhibitor prevented baldness in preadolescent macaques.
September 2018 in “한국자원식물학회지” This study found that oregonin isolated from Alnus japonica exhibits strong antioxidant activity and may promote hair growth, suggesting its potential use in cosmetic products.
April 2016 in “Actas Dermo-Sifiliográficas” The document concludes that a unique target-like hair regrowth pattern in alopecia areata may be more common than thought and should be properly identified.
66 citations
,
May 2002 in “The Plant Journal” This study identified a mutant in Arabidopsis with shorter root hairs due to early growth cessation, implicating the IRE gene in regulating root hair growth duration.
March 2021 in “Annals of palliative medicine” This meta-analysis found that plum-blossom needling, as an add-on therapy, provided moderate beneficial effects on hair regrowth in alopecia areata patients compared to conventional treatment alone.
65 citations
,
September 1999 in “The Journal of Dermatology” In this study, complete to excellent hair regrowth was observed in 63.3% of patients with extensive alopecia areata treated with biweekly dexamethasone pulses, although mild side effects were frequent.
41 citations
,
January 2014 in “Annals of Dermatology” This study found that dermoscopy showed distinctive patterns for different types of alopecia, supporting its clinical usefulness for diagnosing diseases with small round or oval hairless patches on the scalp.