Effects of Cytokines, Anti-Cancer Agents, and Cocarcinogen on DNA Synthesis in Hair Bulb Cells

April 1993 in “ Journal of Dermatological Science ”

Ryusuke Imai, Toshimasa Jindo, K MOCHIDA, Shin Shimaoka, Kenji Takamori, Hideoki Ogawa

cytokines epidermal growth factor gamma interferon doxorubicin cytosine arabinoside tetradecanoyl-phorbolacetate basic fibroblast growth factor DNA synthesis hair germinative cells alopecia EGF IFN-γ Adriamycin Ara-C TPA bFGF

TLDR Certain substances can strongly inhibit DNA synthesis in hair cells.

The study examined the effects of cytokines, anti-cancer agents, and a cocarcinogen on DNA synthesis in human hair germinative cells cultured in serum-free media. It was found that epidermal growth factor and gamma interferon slightly inhibited DNA synthesis, while doxorubicin, cytosine arabinoside, and tetradecanoyl-phorbolacetate caused strong inhibition. Basic fibroblast growth factor had minimal impact on DNA synthesis. This organ culture model was considered useful for studying the effects of various substances on DNA synthesis in hair germinative cells and understanding the pathogenesis of alopecia diseases.

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