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Did you mean DNA fragmentation?

Glossary DNA fragmentation

breaking of DNA strands into smaller pieces

DNA fragmentation refers to the breaking of DNA strands into smaller pieces. This can occur naturally during processes like apoptosis (programmed cell death) or can be induced by external factors such as radiation or certain chemicals. In a clinical or research setting, measuring DNA fragmentation can be important for understanding cell health, diagnosing diseases, or assessing the quality of sperm in fertility studies.

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research Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis

48 citations , December 2019 in “Reproductive Biology and Endocrinology”

This review found an increasing trend in research on sperm DNA fragmentation over the past 20 years, especially focusing on lifestyle factors, asthenozoospermia, and varicocele, with the TUNEL technique as a predominant method.

Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

research Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne

8 citations , February 2010 in “Journal of Dermatology”

This study observed that a topical liposome formulation of a 5‐α‐reductase inhibitor effectively reduced the size of treated sebaceous glands and induced apoptosis in a hamster model, suggesting potential benefits for acne treatment.

research Apoptotic cell death in canine hair follicle.

5 citations , January 2005 in “PubMed”

In this study, researchers observed that apoptosis occurs in both growing and regressing hair follicles in dogs, indicating a spatio-temporal relationship with the hair cycle.

research Forensic DNA phenotyping: the need for proportionate regulation and judicial clarity in law enforcement

March 2026 in “Egyptian Journal of Forensic Sciences”

This review critically examines Forensic DNA Phenotyping, highlighting high accuracy in predicting certain traits but also legal and ethical challenges, particularly around regulatory fragmentation and issues of genetic privacy.

research A Simple Method to Extract DNA from Hair Shafts Using Enzymatic Laundry Powder

8 citations , July 2013 in “PLoS ONE”

This study found that a new method using enzymatic laundry powder effectively extracts DNA from hair shafts, showing promise for genome-wide DNA analyses.

research 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation

September 2017 in “Journal of Investigative Dermatology”

This study found that mackerel fermented fish oil protected human keratinocyte cells from UVB-induced oxidative stress by scavenging free radicals and reducing cellular damage.

research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

253 citations , March 1994 in “Developmental dynamics”

This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.

research Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

46 citations , August 2022 in “Journal of Endocrinological Investigation”

In this study, the authors concluded that COVID-19 may not cause direct long-term harm to testicular function, but temporary indirect effects could occur, suggesting a possible delay in pursuing parenthood post-recovery.

research Effects of High-dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients

February 2026 in “Molecular Imaging and Radionuclide Therapy”

In this study, male patients treated with 150 mCi of radioactive iodine showed no negative impact on fertility, but long-term studies with larger groups are needed to further assess hormonal effects and sperm health after this treatment.

research PD05-10 COMPARATIVE EFFECTS OF FINASTERIDE AND DUTASTERIDE ON SEMEN PARAMETERS IN YOUNG MEN WITH ANDROGENIC ALOPECIA: A RANDOMIZED CONTROLLED STUDY

April 2026 in “The Journal of Urology”

This study found that prolonged use of finasteride and dutasteride in young men with androgenic alopecia is linked to a decline in semen quality over time, particularly affecting sperm motility and DNA integrity, with dutasteride showing a slightly greater impact than finasteride.

research Recent advances in understanding and managing male infertility

104 citations , May 2019 in “F1000Research”

This review discusses recent research on male infertility causes and treatments, emphasizing the need for further understanding of idiopathic sperm abnormalities and molecular factors to improve patient outcomes; it reports no new clinical results.

research Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression

September 2024 in “Chemico-Biological Interactions”

In this study, researchers observed that Finasteride improved cardiac function by enhancing antioxidant levels and reducing oxidative stress in obese and aging rats, though it did not benefit metabolic status and induced insulin resistance in normal diet-fed rats.

research Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications

2 citations , April 2025 in “Biomedicine & Pharmacotherapy”

This research reports that copper-quercetin complexes show strong potential in antioxidation and cancer therapy, while their effects on specific cell death pathways warrant further investigation.

research Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

February 2026 in “Andrology”

This study highlights the need for a comprehensive andrological assessment at diagnosis, including semen and hormonal analysis, to guide fertility preservation strategies, and found that post-orchidectomy semen samples showed improved DNA integrity for assisted reproductive technologies.

research Advantages of Incomplete Digestion in Human Hair Shaft Proteomics, a Focus on Cuticular Keratins

June 2025 in “Rapid Communications in Mass Spectrometry”

In this study, researchers developed a simplified and reliable method to prepare human hair shaft samples, achieving over 75% protein extraction efficiency and improved keratin sequence coverage, with the approach showing high reproducibility across different labs and operators.

research Forensic skeletal and molecular anthropology face to face: Combining expertise for identification of human remains

4 citations , July 2025 in “Annals of the New York Academy of Sciences”

This review emphasizes that collaboration between forensic anthropology and molecular anthropology could significantly improve the identification of unknown human remains by creating more comprehensive biological profiles.

research The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions

January 2026 in “Aging and Disease”

This study highlights the critical role of mitochondria in skin aging and wound repair, suggesting that targeted interventions such as antioxidants, NAD⁺ boosters, and NRF2-based therapies may enhance mitochondrial function and improve cutaneous health.

research Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation

37 citations , March 2012 in “International Journal of Radiation Biology”

This study found that using a 900-MHz GSM mobile phone for 15 or 30 minutes significantly increased single-strand DNA breaks in human hair root cells near the phone.

research Proliferation, DNA repair and apoptosis in androgenetic alopecia

19 citations , August 2008 in “Journal of The European Academy of Dermatology and Venereology”

In this study, researchers observed that in advanced androgenetic alopecia, increased DNA damage in the frontal bald area may lead to cell apoptosis due to impaired repair capacity.

Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes

research Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes

1 citations , October 2025 in “Iranian journal of pharmaceutical research”

This study suggests that geranyl acetate may offer protective, anti-inflammatory, and cytoprotective effects against PPD-induced toxicity in keratinocyte cells, indicating its potential as a plant-derived treatment.

research Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling

January 2026 in “Frontiers in Bioscience-Landmark”

This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage.

Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia

research Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

24 citations , March 2011 in “British Journal of Dermatology”

This study found evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia.

research M5 isolation method preserves higher trichogenic identity and proliferative capacity of human dermal papilla cells

June 2026 in “Applied Biological Chemistry”

This study found that the M5 isolation method for human dermal papilla cells significantly improved attachment efficiency, proliferative capacity, and trichogenic potential, providing an optimized strategy for scalable manufacturing in hair regeneration therapies for conditions like alopecia.

Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

research Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

42 citations , December 2016 in “Cell Death & Differentiation”

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

research Biological effects of human placental extracts - variations in manufacturing methods and compositions

1 citations , December 2025 in “Frontiers in Pharmacology”

This review outlines the biological effects of various placental extracts, noting their reported antioxidant, anti-inflammatory, and immunomodulatory activities, but highlights that the relationship between these effects and the extracts' specific contents remains unclear.

Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

January 2024 in “Aging”

This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.

research Evaluation of apoptosis regulatory markers in androgenetic alopecia

6 citations , December 2010 in “Journal of Cosmetic Dermatology”

This study suggests that low proliferation rates in bald areas of androgenetic alopecia patients, along with persistent inflammatory infiltrate, may lead to follicular miniaturization and fibrosis.

Comparison of the Effectiveness of Different Snare Types for Collecting and Retaining Hair from Eurasian Lynx (Lynx lynx)

research Comparison of the effectivity of different snare types for collecting and retaining hair from Eurasian Lynx (Lynx lynx)

4 citations , March 2012 in “European journal of wildlife research”

This study found that wire brush hair snares collected the most hair from Eurasian Lynx in controlled enclosures, suggesting potential for sampling genetic material from similar felid species.

research Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study

50 citations , May 2011 in “Journal of Ethnopharmacology”

In this cell study, Eclipta alba extract inhibited cancer cell proliferation and induced apoptosis, showing potential antiproliferative and anti-metastasis effects on liver and related cancer cell lines.

Risk Factors for Prostate Cancer: A Case-Control Study Investigating Key Exposures and Gene Interactions

research Risk factors for prostate cancer: a case-control study investigating selected key exposures and their interactions with predisposition genes

December 2010 in “Jurnal Natural (Faculty of Mathematics and Natural Science, Syiah Kuala University)”

This thesis explores both environmental and genetic factors in prostate cancer, focusing on surrogate hormone markers, medical radiation, family history, and genetic polymorphisms related to DNA repair and hormone marker genes, but reports no new clinical findings.