Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that Nubian ibex have developed genetic adaptations in response to their desert environment, including enhanced skin barrier, DNA repair, viral response, and metabolism of toxic compounds.

This study found that PM2.5 exposure induced oxidative stress in human keratinocytes and mouse skin, causing cellular damage, which was mitigated by the antioxidant N-acetyl cysteine.

This study found that minoxidil stimulates the Kir6.2/SUR2 potassium channel, leading to tumor growth arrest in an ovarian cancer xenograft model by disrupting mitochondrial function and inducing cell death.

This article discusses the genomic and postgenomic changes in chronic degenerative diseases and cardiovascular and skin disease contexts, highlighting potential modulation through diet and pharmacological interventions without presenting new experimental results.

This review discusses the preclinical findings on cyproterone acetate and suggests that while it has a low potential cancer risk for patients, its tumor effects in female rats may involve both genotoxic and mitogenic mechanisms.

This source reports that scalp cooling is currently the only safe and FDA-cleared method to potentially reduce chemotherapy-induced hair loss, with about a 50% chance of maintaining sufficient hair to avoid needing a wig.

This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.

This study found that combined loss of Atr and p53 in adult mice led to severe tissue degeneration and delayed regeneration due to the accumulation of highly damaged cells.

This study sequenced and analyzed the goat skin transcriptome, revealing genes involved in signal transduction and cell communication that are differentially expressed during hair growth phases, providing insights for Cashmere goat breeding.

This review discusses how the p53 tumor suppressor gene helps maintain adult tissue homeostasis by promoting the removal of DNA-damaged cells, with implications for treating age-related diseases and p53-deficient cancers; it reports no new results.

This study reported that sunscreen with SPF50+ provides a high level of DNA protection against UV-induced damage in a reconstituted human epidermis model, comparable to that in skin explants.

In this study, high doses of Lepidium sativum seeds extract were reported to cause toxicity and tissue damage in animals, suggesting the need for careful use under medical supervision.

This review discusses dermatophytosis in equines, caused primarily by T. equinum, noting its global prevalence and highlighting diagnostic methods; it reports no new clinical results.

This study identified aging-related epigenetic and transcriptomic biomarkers and suggested that curcumin might target and inhibit the JUN gene, implicating potential therapeutic strategies against aging.

In this study, UVB irradiation of organ-cultured human anagen hair follicles in vitro reduced hair elongation and increased cell death, affecting hair growth and regulatory processes.

This study concluded that laser hair removal using Alexandrite laser emitting red and infrared light appears safe and does not significantly affect the disease activity of Systemic lupus erythematosus.

This chapter reviews formulation principles for creating cosmetic nanoemulsions and applications targeting skin and hair care, but does not present new experimental results.

This consensus concluded that oral isotretinoin is highly effective for treating acne and some off-label conditions, with common adverse events being manageable and rare serious risks not contraindicating use.

This review explores the impact of various medications on male fertility, highlighting reversible negative effects from methotrexate, finasteride, and ketoconazole, while reporting no adverse fertility effects for oral retinoids and certain immunosuppressants.

This review discusses the dermatological adverse events from immunosuppressive and anti-TNF therapy in IBD, finding increased risks of non-melanoma skin cancer and other skin conditions, and recommends regular cancer screening.

This study found that intrinsic reactive oxygen species drive the hair follicle cycle progression through DNA damage and repair, apoptosis, and macrophage polarization, influencing hair loss and regeneration dynamics in mice.

This study found that proton minibeam radiotherapy demonstrated a potential tissue-sparing effect in epidermis models by spatially confining DNA damage, suggesting reduced side effects in radiotherapy.

This study reported that during wheat polyploidization, decreased DNA methylation and specific hypomethylated promoters were associated with altered gene transcription, contributing to root hair elongation and improved nitrate uptake, highlighting the role of epigenetic regulation in enhancing crop traits.

This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by alleviating ROS-mediated DNA damage, rather than enhancing DNA repair.

This study developed a new analytical method to identify a wide range of endocrine disrupting compounds in full-term amniotic fluid, revealing diverse substances with potential endocrine activity.

This study demonstrated that an LC/MS-MS method could effectively detect and quantify the vitamin B3 vitamer nicotinamide in human hair, suggesting its potential use for long-term deficiency examination.

This study introduces "Homeodynamic Rejuvenation" as a method to restore the skin's resilience by enhancing its ability to detect and recover from stress, focusing on five core biological processes critical for maintaining skin function and health amidst environmental and metabolic challenges.

This study reports that LED phototherapy is gaining popularity as a safe and effective non-invasive method for treating various skin conditions, enhancing skin rejuvenation, wound healing, and inflammation modulation, and is increasingly integrated into clinical protocols for conditions like acne vulgaris and signs of aging.

This study indicated that a novel calcium-phosphate nanoflower coating on titanium surfaces had high surface area, low cytotoxicity, and promising cell affinity, suggesting it could be a potential alternative modification method for titanium implants.

This review highlights that pomegranate exhibits promising beneficial effects in preclinical and clinical studies for cardiovascular and non-cardiovascular diseases, though further research is needed on its bioavailability and metabolites for effective therapeutic use.