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Glossary Dermal Melanocytes

specialized skin cells producing pigment in the dermis

Dermal melanocytes are specialized cells located in the dermis, the deeper layer of the skin, that produce melanin, the pigment responsible for skin color. Unlike the more common epidermal melanocytes found in the outer skin layer, dermal melanocytes are involved in certain pigmentation disorders and can contribute to conditions like dermal melanocytosis, which results in blue or gray patches on the skin.

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research Cutaneous Manifestations of Mucopolysaccharidoses

8 citations , September 2016 in “Pediatric dermatology”

This review discusses the diverse clinical manifestations of mucopolysaccharidoses in children and emphasizes the importance of early diagnosis and treatment initiation, but it reports no new clinical findings.

research Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice

10 citations , November 2010 in “Pigment Cell & Melanoma Research”

This study found that epidermal melanocytes can regenerate hair follicles, whereas non-cutaneous or dermal melanocytes cannot, suggesting two distinct melanocyte lineages with potential implications for melanocyte-related diseases.

research Role of Dermal Melanocytes in Cutaneous Pigmentation of Stasis Dermatitis

2 citations , January 2002

This study investigated the pigments and cells causing discoloration in stasis dermatitis but did not clarify the role of melanin or melanocytes in this condition.

research Sox2 in the dermal papilla regulates hair follicle pigmentation

9 citations , July 2022 in “Cell reports”

This study found that Sox2 within dermal papilla cells in the hair follicle regulates hair pigmentation, influencing the type and production of melanin.

research Steroidogenic factor-1 lineage origin of skin lesions in Carney complex syndrome

January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study suggests that typical skin lesions in Carney complex may originate from the pro-melanogenic activity of a specific dermal fibroblast population influenced by PKA signaling.

research Melasma in Men

1 citations , January 2015 in “Journal of Pigmentary Disorders”

This article reviews melasma in men, its causes, and treatment options, but reports no new clinical findings.

research A rare case of pigmented nodular alopecic lesion on the scalp

January 2024 in “QJM”

This study reported the case of a 30-year-old man with a bluish-grey scalp nodule that developed over a previously stable hairless plaque, revealing histopathological features consistent with epithelioid cell nests and spindle-shaped dermal melanocytes embedded in collagen.

research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

This review examined and discussed the role of dermis-derived factors in the regulation of melanogenesis, noting their significance in both normal and abnormal mammalian skin conditions, suggesting an underexplored area of study compared to dermal and epidermal influences.

research Medical aesthetics – Current trends and a review of its applications

9 citations , January 2023 in “Indian Dermatology Online Journal”

This review discusses the use of aesthetic treatments for medical purposes and their therapeutic potential but provides no new clinical results.

research Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome

3 citations , May 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that skin pigmentation alterations in a mouse model of Carney complex may be caused by specific dermal fibroblasts promoting melanogenic signaling.

research Development of Heritable Melanoma in Transgenic Mice

75 citations , March 1998 in “Journal of Investigative Dermatology”

This study reports that transgenic mice carrying Clone B DNA developed spontaneous melanomas likely due to an interruption in genes regulating cell growth in melanin-producing cells, offering a model for melanoma research.

Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles

research Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair follicles

39 citations , January 2008 in “Journal of Endocrinology”

This study found that in androgenetic alopecia, reduced stem cell factor production by dermal papilla cells may lead to decreased pigmentation in hair follicles.

research ‘Malignant melanoma microecosystem’: Immunohistopathological insights into the stromal cell phenotype

8 citations , January 2011 in “Experimental and Therapeutic Medicine”

This review summarizes the characteristics of the peri-malignant melanoma stroma, indicating its potential role in early dermal metastatic migration and increased metastasis risk.

research Keratinocytes regulate the function of melanocytes

55 citations , December 2014 in “Dermatologica sinica/Zhōnghuá pífūkē yīxué zázhì”

This article discusses the interactions between keratinocytes and melanocytes in maintaining epidermal and hair follicle homeostasis, without reporting new experimental results.

Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

10 citations , May 2016 in “Journal of Dermatological Science”

This study found that PDGF-BB affects human melanocytes differently depending on their differentiation stage, stimulating melanoblast proliferation but inhibiting melanocyte proliferation while promoting their differentiation.

research Temporary radiation-induced alopecia after embolization of a cerebral arteriovenous malformation

9 citations , October 2014 in “Clinical and Experimental Dermatology”

Temporary hair loss can occur after brain AVM treatment but usually regrows in 8 weeks.

research Acanthosis nigricans and the metabolic syndrome

30 citations , September 2017 in “Clinics in Dermatology”

This article reviews the clinical and histological features of acanthosis nigricans and its associations with insulin resistance and other conditions, but highlights the need for more research on its classification, severity assessment, and treatment options.

research Efficacy of an agonist ofα-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation

12 citations , September 2018 in “International Journal of Cosmetic Science”

This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.

Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus

research Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus

4 citations , August 2017 in “International journal of molecular sciences”

This study observed two cases of pigmented epithelioid melanocytoma suggesting potential differing origins: one from a hair follicle's outer root sheath and another from an intradermal nevus.

research Racial and Gender Influences on Skin Disease

January 2018 in “Springer eBooks”

Different races and genders have unique skin and hair issues, requiring specialized care and more research for effective treatment.

research Bioengineering Skin Constructs

1 citations , November 2014 in “Elsevier eBooks”

This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.

research Surgical Management of Leukotrichia

October 2006

This chapter reviews surgical management techniques for leukotrichia in vitiligo and presents no new clinical findings; it highlights various grafting and epilation methods.

Literature Review on Atopic Dermatitis and Related Studies

research LITERATURE REVIEW

May 2004 in “Pediatric Dermatology”

Atopic dermatitis may have genetic causes and can be treated with pharmacologic methods, glycerin creams, and controlling Staphylococcus aureus colonization.

Differences in Perceptions of Beauty and Cosmetic Procedures in Ethnic Patients

research Differences in Perceptions of Beauty and Cosmetic Procedures Performed in Ethnic Patients

49 citations , June 2009 in “Seminars in Cutaneous Medicine and Surgery”

This article examines differences in aging among ethnic populations and highlights cosmetic procedures specific to skin of color, but reports no new research findings.

Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

research Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

41 citations , December 2018 in “Experimental Dermatology”

This review explores recent findings on the roles of melanocyte and melanocyte stem cells in the hair follicle, highlighting their importance for skin health and potential applications in regenerative medicine, but reports no new clinical results.

research Forensics in dermatology: Part II

16 citations , April 2011 in “Journal of The American Academy of Dermatology”

This article overviews dermatologic findings in forensic pathology and reports no new results; it emphasizes the importance of recognizing skin manifestations in identifying types of injury.

research To study the prevalence of cutaneous manifestationsin newborns and its correlation with defined maternal and neonatal factors

2 citations , June 2016 in “International Journal of Medical Research and Review”

This study found that Epstein pearls and Mongolian spots are the most common skin lesions in newborns in India, influenced by interracial, environmental, and hormonal factors.

Dermatological Particularities, Physiological Aspects, and Dermatoses in Black Skin

research Particularidades dermatológicas, fisiológicas e as dermatoses na pele negra

1 citations , December 2024 in “Revista Eletrônica Acervo Saúde”

This article reviews dermatological research on black skin, emphasizing its unique physiological characteristics and common conditions like acne and eczema, and suggests more focus is needed on its structural differences and clinical responses.

research Index

November 2019 in “Harper's Textbook of Pediatric Dermatology”

This index of Harper's Textbook of Pediatric Dermatology, Fourth Edition, provides no clinical results or new findings.

research Alopecia Totalis Treated with 1064 nm Picosecond Nd:YAG Laser: A Case Report

March 2019 in “Applied sciences”

This case report suggests that 1064 nm picosecond Nd:YAG laser therapy may effectively improve alopecia totalis when used as an alternative adjuvant treatment, as demonstrated in a split-scalp study showing better results than steroid treatment alone.