This section presents 70 multiple choice questions designed for haematology specialist trainees, covering complex clinical cases and their likely diagnoses, adverse events, and management advice.
2 citations
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September 2022 in “Annals of Oncology” This study observed that MIRV improved gastrointestinal symptoms and other quality of life measures in patients with platinum-resistant ovarian cancer compared to chemotherapy.
79 citations
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March 2017 in “Dermatologic clinics” This review discusses the complex systemic nature of vitiligo and its associations with autoimmune conditions, emphasizing the need for increased understanding and awareness of related comorbidities and psychological effects.
21 citations
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June 2023 in “Journal of Nanobiotechnology” This review explores current strategies to enhance extracellular vesicle-based delivery of CRISPR/Cas systems, addressing efficiency challenges and suggesting future directions to bridge gene editing technologies with clinical applications.
April 2023 in “Journal of Investigative Dermatology” This study explored COVID-related chilblains using transcriptomics and found they showed a distinct interferon and JAK/STAT pathway activation, absent in vaccine-related chilblains, with inflammatory cell types varying over time.
May 2018 in “Journal of Clinical Oncology” This study observed that a combination of low-dose cyclophosphamide and vinorelbine appears safe and has promising antitumor activity in patients with metastatic breast cancer resistant to anthracyclines and taxanes, achieving a 44% objective response rate at 6 months with manageable toxicity levels.
34 citations
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April 2008 in “Journal of the European Academy of Dermatology and Venereology” This study reported that while lichen planus was not significantly linked to hepatitis C virus infection, pruritus, dry skin, and hair loss were more common in HCV patients post-interferon treatment.
11 citations
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January 2009 in “World Journal of Gastroenterology” This study reports the first documented case of Cronkhite-Canada syndrome in a patient with myelodysplastic syndrome, where corticosteroids dramatically improved the patient's condition.
May 2024 in “Animal genetics” The researchers investigated a Maine Coon cat with suspected classical Ehlers-Danlos Syndrome and discovered a heterozygous deletion in the COL5A1 gene, underscoring the value of whole-genome sequencing for precise veterinary diagnostics.
11 citations
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July 2014 in “Clinical Rheumatology” This study found that Chinese female patients with systemic autoimmune diseases treated intravenously with cyclophosphamide were more likely to experience gastrointestinal discomfort, myelosuppression, and alopecia.
January 2010 in “Journal of The American Academy of Dermatology” The document provided instructions for completing a CME exam on diagnosing and managing hair loss.
research Coda
November 2018 in “Princeton University Press eBooks” This chapter discusses the roles of vitamin C in brain function and its potential impact on behavior during periods of deficiency, reporting no new experimental findings.
30 citations
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May 2015 in “Current Cardiology Reviews” This review analyzed observational studies on endogenous sex steroids and CVD risk, reporting mixed findings: lower testosterone and higher estradiol levels were associated with increased CVD risk, but significant literature gaps remain.
March 2015 in “Polish Journal of Public Health” This study found that capillaroscopic patterns varied among patients with systemic scleroderma, psoriasis, psoriatic arthritis, and alopecia, suggesting potential microcirculation disturbances; however, no correlations were observed with serum angiogenic markers.
October 2024 in “Journal of the Endocrine Society” This study examined uncharacterized CYP21A2 gene variants related to non-classic congenital adrenal hyperplasia and found that several mutations reduce enzyme activity, which may help improve diagnostic and treatment strategies.
January 2024 in “Biomedicines” This review discussed the cutaneous manifestations of APECED, highlighting chronic mucocutaneous candidiasis, alopecia areata, and vitiligo, while emphasizing the importance of early detection and monitoring for accurate diagnosis and patient care in various populations.
May 2001 in “Hair transplant forum international” This article discusses the use of a high-magnification digital video microscope for diagnosing and treating androgenetic alopecia and reports no new clinical results.
26 citations
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January 1992 in “Cancer investigation” This study found that N-acetylcysteine effectively prevented cyclophosphamide-induced alopecia in rats, and ImuVert plus N-acetylcysteine prevented alopecia from a cyclophosphamide-cytarabine combination.
October 2007 in “Clinical Biochemistry” This study identified a new genotype, V281+I172N/V281L, linked to non-classical 21-hydroxylase deficiency, suggesting it should be considered in genetic panels for the condition.
1 citations
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June 2022 in “Jambura Journal of Mathematics” This review analyzes the research on production delivery strategies using n-vehicle, highlighting recent developments and suggesting areas for future study, but it reports no new experimental findings.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers observed that blood vessel maturation in mice involves neonatal endothelial cells expanding the capillary network through vessel regression and angiogenesis, with adult cells later maintaining stability and repair through specific signaling pathways.
304 citations
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July 2006 in “Journal of The American Academy of Dermatology” This study found that videodermoscopy enhances diagnostic accuracy for scalp and hair disorders beyond simple clinical inspection and reveals novel disease features that could improve clinical understanding.
2 citations
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January 2019 in “Springer eBooks” This review discusses segmental vitiligo as part of the vitiligo clinical spectrum and highlights its role as a model for studying repigmentation, but reports no new clinical results.
5 citations
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July 2020 in “Experimental Physiology” This study found that the dynamic characteristics of both cerebrovascular carbon dioxide reactivity and central respiratory chemoreflex decrease in the high frequency range and are not modified by exercise.
1 citations
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December 1996 in “Cell Biology and Toxicology” This study reviews the medicinal uses of Catharanthus roseus, highlighting its production of valuable anticancer alkaloids like vincristine and vinblastine, and its applications in treating diabetes, hypertension, and infections, but also notes potential side effects such as nausea and myelosuppression, especially at high doses.
3 citations
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October 2022 in “Clinical, Cosmetic and Investigational Dermatology” This study found that repetitive 532 nm laser therapy significantly decreased scores for macules, pigmented, and vascular lesions on the facial area, regardless of skin phototype or age.
4 citations
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January 2016 in “Dermatology practical & conceptual” This report describes the first known case of Kaposi's varicelliform eruption occurring after a follicular unit extraction procedure, possibly linked to surgical trauma and post-surgical steroid use.
October 2023 in “The American Journal of Gastroenterology” This case report describes chronic iron deficiency anemia in a patient with Cronkhite-Canada syndrome, highlighting the need for more data to guide treatment and cancer surveillance due to its rarity and mortality risk.
60 citations
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February 2015 in “Biomaterials” In this study, immobilized VEGF selectively captured endothelial cells under various shear stresses, suggesting its potential for promoting endothelialization in vascular grafts or implanted tissues.