Cronkhite-Canada Syndrome Associated with Myelodysplastic Syndrome

    January 2009 in “ World Journal of Gastroenterology ”
    Rei Suzuki, Atsushi Irisawa, Takuto Hikichi, Yuta Takahashi, Hiroko Kobayashi, Hiromi Kumakawa, Hiromasa Ohira
    TLDR A woman with both Cronkhite-Canada syndrome and myelodysplastic syndrome improved significantly with corticosteroid treatment.
    This case study reported the first known instance of Cronkhite-Canada syndrome (CCS) in a 54-year-old woman who also had myelodysplastic syndrome (MDS). The patient presented with symptoms including epigastric discomfort, dysgeusia, alopecia, atrophic nail changes, and palm pigmentation. Severe hypoalbuminemia was detected through blood tests, and a colonoscopy revealed numerous polyps. Biopsy results were consistent with CCS, showing stromal edema, lymphocyte infiltration, and cystic dilatation of the crypt. Treatment with corticosteroids led to significant improvement in her symptoms, laboratory results, and endoscopic findings.
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