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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Nonionic liposomes are the best for delivering genes to skin cells.

Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

Scalp cooling can reduce chemotherapy-induced hair loss and should be available in all hospitals.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.

Autophagy is important for human hair growth and health.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

The study concluded that scalp tumors show different patterns based on age, gender, and tumor thickness, and emphasized the importance of early detection and scalp examinations.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Early recognition and management of skin side effects from new cancer therapies can prevent treatment delays.

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.