19 citations
,
May 2014 in “Molecules” This study found that the methanolic heartwood extract of Avicennia marina significantly inhibits 5α-reductase type 1, reducing 5α-DHT production by 52% in a cell-based assay with human hair dermal papilla cells.
This study found that soups with 5% and 10% hibiscus flower were more desirable in sensory attributes and had higher β-carotene content compared to the control soup.
9 citations
,
April 2019 in “Food Chemistry” This study developed an efficient method for converting polymeric procyanidins into high-purity oligomeric procyanidins using a semisynthetic approach combined with separation techniques.
January 2022 in “Current Enzyme Inhibition” This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.
48 citations
,
May 2021 in “Molecules” The researchers found that plant extracts from Papaver rhoeas L., Clitoria ternatea L., and Carthamus tinctorius L. are effective natural cosmetic dyes, offering intense and stable colors without cytotoxicity.
16 citations
,
October 2018 in “BMC Complementary and Alternative Medicine” In this animal study, the methanolic extract of Crataeva nurvala leaves was found to possess sedative and anxiolytic properties, potentially linked to GABAergic activity and certain neuroactive compounds.
193 citations
,
February 2015 in “Nature Communications” Fungi-produced compounds can change plant root growth.
June 2022 in “Journal of the turkish academy of dermatology” In this study, metabolic syndrome and hypertension were significantly more prevalent in patients with plantar callosities compared to controls, suggesting potential links that warrant further investigation.
July 2023 in “Eurasian journal of science and engineering” In this study, researchers reviewed various traditional herbal remedies, such as Tribulus terrestris and Matricaria chamomilla, focusing on their global medicinal use and discussing some of the chemical components that contribute to their biological activity.
March 2012 in “Daehan hwajangpum hakoeji/Daehan hwa'jangpum haghoeji” This study observed that a cream containing functional compounds from medicinal plants increased collagen production in human skin, while a hair tonic enhanced hair growth in mice.
June 2021 in “International Journal of Biosciences (IJB)” This study reports that both aqueous and methanolic extracts of Tridax procumbens flowers demonstrated antibacterial activity against selected bacteria, indicating potential as antibacterial agents.
December 2023 in “Research Square (Research Square)” In this study, researchers using molecular docking techniques found that 12-Methoxy carnosic acid from rosemary shows promising potential as a natural inhibitor of the 5 alpha reductase enzyme, which is involved in hair loss, suggesting its efficacy compared to finasteride.
In this study, human dermal papilla cells exposed to wasabi leaf extract showed changes in cytokine-related gene expression, which the authors suggest could help clarify the biological effects of wasabi.
This literature review suggests that herbal extracts show promise as antiandrogenic agents for androgen-related conditions, potentially offering a natural alternative with fewer side effects than synthetic medications.
August 2022 in “Indonesian Journal of Medical Chemistry and Bioinformatics” This in-silico study identified several compounds as potential Vitamin D Receptor agonists, with Dolichosterone showing the strongest binding energy.
6 citations
,
April 2017 in “Frontiers in Pharmacology” This study found that several compounds from Yangxue Shengfa capsule may promote hair growth by enhancing cell proliferation in vitro, suggesting potential use in treating androgenetic alopecia.
April 2026 in “Inflammopharmacology” This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.
6 citations
,
January 2023 in “Evidence-based Complementary and Alternative Medicine” This review discusses the use of yoga and herbal remedies for managing PCOS, reporting improved symptoms, hormonal balance, and quality of life, but presents no new clinical results.
13 citations
,
August 2019 in “Biological & Pharmaceutical Bulletin” This study found that flavonoids with two hydroxyl groups in their B-ring, such as sterubin and luteolin, supported the regeneration of pigmented hair after skin injury, unlike those with one hydroxyl group.
24 citations
,
January 2015 in “Annals of Dermatology” In this study, herbal extracts commonly used in traditional medicine were observed to significantly increase the proliferation of human dermal papilla cells, suggesting potential as alternative therapies for enhancing hair growth.
November 2024 in “International Journal of Plant and Environment” This study analyzed Sphenodesme involucrata var. paniculata leaves and found high carbohydrate and calcium content, along with several bioactive compounds, supporting their use in traditional medicine for their nutrient-rich properties.
December 2017 in “Dong-ui saengni byeongni hakoeji” This study found that Cynanchi Wilfordii Radix has strong antioxidant activity and may reduce key factors involved in male hair loss in dermal papilla cells.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers formulated a natural shampoo using curcumin, flaxseed oil, and lavender oil, finding it effective in cleansing and conditioning hair, with higher solid content enhancing dirt removal and lower viscosity aiding application, though further refinement is needed for overall improvement.
1 citations
,
April 2009 in “한국생물공학회 학술대회” In this study, onion (Allium cepa) extracts promoted hair growth in an alopecia model in mice, with the effect appearing unrelated to the presence of the polyphenol quercetin.
2 citations
,
January 2025 in “Frontiers in Pharmacology” In a rat model of benign prostatic hyperplasia, this study found that purple corn extract may improve symptoms by inhibiting prostate enlargement, reducing androgen receptor signaling, and exerting anti-inflammatory effects.
In this study, researchers found that crude extracts from Avicennia marina and its component avicequinone C inhibit mechanisms contributing to androgenic alopecia in vitro, including 5α-reductase activity and DHT-AR interactions, potentially promoting hair growth and delaying the catagen phase in human dermal papilla cells.
2 citations
,
December 1988 in “PubMed” This study concluded that there was clear evidence of carcinogenic activity of C.I. Acid Orange 3 in female F344/N rats but not in male rats or B6C3F1 mice of either sex.
This study found that an extract treatment showed similar efficacy and tolerability to calcipotriol/betamethasone ointment in reducing psoriasis severity and symptoms over 28 days in patients with mild-to-moderate plaque psoriasis.
2 citations
,
May 2025 in “PLoS ONE” This study found that a 4:1 combination of Rhynchosia nulubilis and Polygonum multiflorum extracts significantly promoted the proliferation of human dermal papilla cells and alleviated testosterone-induced cytotoxicity, suggesting potential for treating hair loss and related disorders through a synergistic approach.
5 citations
,
July 2022 in “IBRO Neuroscience Reports” This study found that camphor and similar compounds depress neural activity in rat mechanoreceptors, suggesting that their effects may not be mediated through TRP channels.