February 2013 in “Archives of Disease in Childhood: Education & Practice” Different types of alopecia in children require specific diagnoses and treatments.
July 1988 in “Journal of The American Academy of Dermatology” This article reviews therapeutic advances published between December 1986 and December 1987 but reports no new research findings; readers are advised to consult the original articles before considering new therapies.
6 citations
,
March 1996 in “Journal of Investigative Dermatology”
1533 citations
,
October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
788 citations
,
February 2007 in “Nature” This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.
721 citations
,
October 2011 in “Nature” Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.
658 citations
,
June 2003 in “Endocrine reviews” This review discusses the role of androgens in the progression of cardiovascular disease and explores novel therapeutic targets without reporting new clinical results.
551 citations
,
November 2013 in “Nature” This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.
351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
326 citations
,
February 2009 in “The American journal of pathology” This review discusses the role of Lgr5 as a marker for identifying adult stem cells, particularly in the intestine and hair follicles, and reports no clinical results.
293 citations
,
November 2011 in “Nature” This study found that the circadian clock regulates the activation state of murine epidermal stem cells, affecting tissue homeostasis and susceptibility to tumorigenesis when disrupted.
291 citations
,
April 2010 in “Gastroenterology” This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.
271 citations
,
March 1999 in “Developmental biology” This study reveals that overexpression of Wnt3 in transgenic mouse skin leads to a short-hair phenotype and cyclical balding due to structural defects in hair shafts, highlighting a role for WNT signaling in hair growth regulation.
254 citations
,
January 2012 in “Nature Reviews Molecular Cell Biology” This review discusses the role of stem cell progeny as integral components of stem cell niches, offering feedback that may influence different stem cell systems' microenvironments, but it presents no new research findings.
248 citations
,
December 2011 in “Journal of Neuroscience” This study demonstrated that stress-derived neurosteroid THDOC shifts from inhibiting to activating the HPA axis under stress, presenting potential therapeutic targets for stress-related disorders.
248 citations
,
November 2011 in “The EMBO Journal” This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.
243 citations
,
September 2016 in “Dermatology and Therapy” This article provides an overview of how dermoscopy can aid in the noninvasive diagnosis of various general dermatological disorders, grouped by clinical presentation, but reports no new clinical results.
238 citations
,
March 2013 in “Development” This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.
237 citations
,
February 2016 in “Science Translational Medicine” This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
218 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
202 citations
,
August 2017 in “Nature cell biology” This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.
184 citations
,
November 2014 in “Developmental Cell” This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.
184 citations
,
September 2006 in “PLoS Genetics” This study found that loss of Apc due to K14-cre-mediated gene recombination in mice led to aberrant growth in ectodermally derived squamous epithelia, implicating its critical role in specifying epithelial cell fates during embryonic development.
182 citations
,
June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.
182 citations
,
June 2002 in “Journal of Neuroscience” This study suggests that apoE4 may contribute to cognitive decline by reducing androgen receptor levels in the brain, but androgen treatment improved memory deficits in female mice expressing human apoE4.
165 citations
,
September 2001 in “Genes & development” This study found that Cutl1 mutant mice experienced retarded lung differentiation and abnormal hair follicle morphogenesis, indicating the vital role of CDP in lung development and hair follicle cell-lineage specification.
164 citations
,
April 2008 in “Cochrane library” This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.
160 citations
,
January 2017 in “Development” This study found that hypertrophic chondrocytes at the fracture callus border may convert to osteoblasts, influenced by vasculature and pluripotency gene expression.