June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study evaluated petroleum jelly-based bioactive glass ointments with varying copper concentrations for wound healing in chronic wound models, finding that the 3 wt% copper formulation significantly improved healing by enhancing tissue regeneration, vascularization, and antibacterial protection compared to controls.
June 2026 in “Journal of Biomedical Materials Research Part B Applied Biomaterials” This study found that a hydrogel made from human placenta-derived ECM, copper, and endothelial progenitor cells significantly enhanced pressure ulcer healing in a mouse model by improving wound closure and tissue regeneration.
In this experimental study, researchers found that using aluminum foil in hair bleaching significantly improves lightness and color uniformity compared to not using foil, indicating a more effective technique for achieving optimal hair coloring results.
September 2025 in “ACS Applied Materials & Interfaces” The researchers reported that a newly developed photo-cross-linked hydrogel with multifunctional properties, including antimicrobial and antioxidant effects, significantly improved diabetic wound healing, achieving over 90% wound closure in seven days in vivo.
February 2025 in “JAAD International” Five monthly sessions of minoxidil-dutasteride-copper peptide tattooing significantly improve hair regrowth in men with androgenetic alopecia.
January 2025 in “Open Veterinary Journal” This study found that sheep with deficiencies in zinc, copper, and vitamin A exhibited symptoms like weight loss, skin disorders, and abnormal hematological and antioxidant enzyme levels compared to healthy sheep, suggesting that dietary supplementation of these nutrients could prevent these health issues.
June 2024 in “Indian Journal of Veterinary Medicine” This case report describes a Salem black kid with alopecia and other symptoms, which was diagnosed with anaplasmosis due to Anaplasma ovis infection combined with copper deficiency, as confirmed by laboratory tests including blood smears and serum biochemistry.
March 2024 in “BMC women's health” This study found that free testosterone levels were 29% higher with the levonorgestrel implant than with the DMPA injection, which may impact sexual function, mood, and side effects like acne.
January 2024 in “Advanced Healthcare Materials” In a mouse model of androgenetic alopecia, this study developed a treatment combining a copper-curcumin nanoparticle oleogel with traditional Gua Sha therapy, which augmented hair regeneration more effectively than minoxidil by improving the follicular microenvironment and regulation of inflammatory responses.
June 2023 in “Research Square (Research Square)” This study demonstrated that dietary cupric citrate improved growth performance and nutrient utilization in broilers, while also altering their intestinal microbiota and increasing the pH in the duodenum and jejunum.
November 2021 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This paper evaluates the therapeutic response of androgenetic alopecia to topical application of specific compounds using digital drug delivery but reports no new clinical results.
January 2013 in “Food science and technology research” This study reported that green tea extract may promote the excretion of copper into the hair in mice.
December 2012 in “Bulletin of Egyptian Society for Physiological Sciences” This study found that topical application of copper (II) albumin complex improved healing signs in rats with full thickness thermal burns, enhancing antioxidant, anti-inflammatory, and pain modulating effects.
July 1998 in “Hair transplant forum international” This article discusses the need to focus on improving telogen effluvium and healing speed in hair transplantation but reports no new research findings.
April 1981 in “Pediatric research” This study found that abnormal liver and kidney copper metabolism in Br females had no clinical effects, whereas defective brain copper metabolism in Br males was clinically significant.
In this study, a copper-deficient diet in rats led to a significant decrease in blood and liver copper levels without causing clinical symptoms, while hair leachable copper and bone copper remained unchanged.
January 2022 in “Social Science Research Network” This study demonstrates that a newly developed nanocomposite microneedle patch, releasing copper and zinc ions along with quercetin, effectively promotes hair follicle regeneration in androgenic alopecia by targeting various pathophysiological aspects of hair loss.
52 citations
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December 1984 in “Journal of the American Geriatrics Society” This study found that serum and hair mineral concentrations, including copper and zinc, showed no differences between Alzheimer's patients and their healthy spouses, suggesting no diagnostic utility for Alzheimer's disease.
26 citations
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October 2011 in “Biological trace element research” This study observed that lower serum copper levels may be linked to premature hair graying in young patients compared to controls.
4 citations
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June 1980 in “American Journal of Clinical Nutrition” Malnutrition can change hair color due to altered copper and zinc levels.
January 2026 in “International Journal of Pharmaceutical Quality Assurance” In this study, researchers observed that patients with Alopecia Areata had significantly lower serum zinc and higher copper levels compared to healthy controls, indicating a disrupted zinc-copper balance that may contribute to the disease's pathogenesis.
September 2024 in “African Journal of Biomedical Research” This study found that individuals with alopecia areata had significantly lower blood levels of vitamin D and slightly lower serum copper levels compared to healthy controls, suggesting the potential importance of assessing these factors in the chemical evaluation of patients with this condition.
17 citations
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January 1981 in “International Journal of Food Sciences and Nutrition” This article reviews the roles of zinc and copper in biological processes, especially their implications for metabolism and deficiency-related disorders, but it does not present new clinical results.
4 citations
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October 2011 in “Medical journal of Tabriz University of Medical Sciences and Health Services” This study suggests that lower levels of zinc and copper in hair and serum, along with altered oxidative stress markers, may contribute to the development of alopecia areata and androgenetic alopecia.
2 citations
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January 1977 in “PubMed” 1 citations
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January 1985 in “IRIS UNIMORE (University of Modena and Reggio Emilia)” September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, researchers developed a multifunctional hydrogel (FVP@CCN) that demonstrated over 90% wound closure in 7 days in diabetic wound models, thanks to its antibacterial, antioxidant, anti-inflammatory, and angiogenesis-promoting properties.
January 2004 in “Weiliang yuansu yu jiankang yanjiu” This study found that copper levels varied significantly by gender, while young infants had higher levels of copper, zinc, calcium, magnesium, and iron compared to older age groups.
2 citations
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January 2011 in “프로그램북(구 초록집)”