343 citations
,
December 2008 in “Endocrine Reviews” This review discusses the various evidence-based and potential applications of metformin in treating and preventing symptoms and complications associated with polycystic ovary syndrome but reports no new clinical results.
288 citations
,
June 2009 in “Human reproduction update” This review examines various methods for assessing hair growth in women, highlighting the usefulness of the mFG visual scoring method for diagnosing hirsutism despite its limitations.
277 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
269 citations
,
August 2002 in “Journal of The American Academy of Dermatology” This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.
232 citations
,
January 2016 in “BMC Bioinformatics” This study found that using curated biomedical databases as training examples for information extraction tasks in Genome-Wide Association Studies can outperform cost-insensitive methods, demonstrating their potential use without expert annotation.
227 citations
,
January 1998 in “Journal of Endocrinology” This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.
219 citations
,
March 2004 in “Journal of The American Academy of Dermatology” In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.
213 citations
,
June 2017 in “Rheumatology” This guideline outlines the management of systemic lupus erythematosus in adults but reports no new clinical findings.
210 citations
,
November 2015 in “The Lancet HIV” This study observed that while PrEP was effective among transgender women if taken, adherence was low, especially among those at higher risk.
202 citations
,
August 2017 in “Nature cell biology” This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.
183 citations
,
January 1987 in “British Journal of Anaesthesia” This article discusses the long-standing use and safety of opioids in anaesthesia, noting that respiratory depression is a manageable side effect due to the availability of opioid antagonists.
176 citations
,
August 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, cross-sex hormone therapy affected hair growth patterns differently, with estrogen reducing hair growth in male-to-female transsexuals and testosterone increasing it in female-to-male transsexuals; however, male typical hair diameters were not fully reached in the latter group after 12 months.
164 citations
,
April 2008 in “Cochrane library” This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.
159 citations
,
November 2007 in “American Journal of Pathology” In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
147 citations
,
January 2014 in “American Journal of Clinical Dermatology” This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.
140 citations
,
December 2017 in “Journal of Controlled Release” This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
138 citations
,
October 2012 in “Behavioral Ecology” This review argues that the immunocompetence hypothesis, linking masculine facial features to attractiveness through health benefits, lacks sufficient evidence and sidesteps alternative explanations.
131 citations
,
October 2004 in “Clinical Cancer Research” This study suggests that applying topical Tempol to the scalp before whole brain radiation may protect against radiation-induced alopecia and is safe and well-tolerated.
130 citations
,
January 1994 in “Differentiation” In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
130 citations
,
September 1990 in “Journal of the American Academy of Dermatology” This study found that combining flutamide with an oral contraceptive significantly reduced hirsutism, acne, and seborrhea in patients after seven months, without significant side effects.
124 citations
,
August 1990 in “British Journal of Dermatology” Diffuse alopecia in women may be related to androgens and iron deficiency, and basic hormone and nutrient screening is useful.
121 citations
,
March 1989 in “Journal of Investigative Dermatology” Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” This review provides an overview of recent tissue engineering and regenerative medicine developments in Asia, highlighting significant advances, representative research achievements, and discussing future directions, without presenting new research results.
119 citations
,
October 2011 in “Journal of Veterinary Internal Medicine” This review discusses the clinical manifestations and immune response to Rhodococcus equi infection in foals but reports no new clinical results.
108 citations
,
November 1980 in “British Journal of Dermatology” This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.
107 citations
,
August 2014 in “Dermatologic Surgery” This pilot study suggests injecting platelet-derived growth factors into the scalp may offer some clinical benefits for androgenetic alopecia, though further randomized trials are needed for confirmation.
96 citations
,
October 2000 in “The FASEB Journal” In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.
94 citations
,
July 2020 in “European Journal of Human Genetics” This article provides guidelines for molecular genetic testing of congenital adrenal hyperplasia due to 21-hydroxylase deficiency, focusing on quality requirements, methodologies, and variant classification; it reports no new clinical results.
94 citations
,
January 2016 in “Journal of the European Academy of Dermatology and Venereology” Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.
89 citations
,
September 2010 in “Annual Review of Genomics and Human Genetics” This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.