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The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Androgen use may increase the risk of stroke, but more research is needed.

Removing both ovaries may better treat increased male hormone levels and related symptoms in postmenopausal women when hormone therapy doesn't work.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Genes and epigenetic changes are important in the development of Polycystic Ovary Syndrome.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.

Diabetic neuropathy in mice is linked to poor mitochondria function and lower brain hormone production.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.