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Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Valproic acid may help hair grow and could be a safe treatment for hair loss.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

The conclusion is that androgen receptor gene polymorphism might be a marker for polycystic ovary syndrome, but more research is needed.

Some skin conditions look like acne but are caused by drugs, and they usually get better when the drug is stopped.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

A 17-year-old developed woolly hair nevus in adolescence, which is unusual, and over time the hair darkened and straightened slightly, but microscopic changes persisted.

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.

EVG staining is a valuable, simple, and cost-effective method for diagnosing various skin conditions in dermatopathology.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

Facial rejuvenation surgery has evolved to yield natural results with low complication rates, and more men and older patients are choosing this surgery.

Valproic acid increases hair count in men with hair loss.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Bimatoprost was found to be safer and more effective than mometasone furoate for treating scalp hair loss.

Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.

The document concludes that there is no clear definition of adequate health insurance, and a consistent method to measure underinsurance is needed.

CD98hc's role in skin health decreases with age.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.