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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Myrtle has various health benefits and potential for medicine development.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Insulin resistance in women with PCOS can lead to serious health issues, but lifestyle changes and certain medications can help manage symptoms.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Suppressing certain hormones might help prevent prostate cancer.

Taiwanese women with PCOS experience different symptoms based on age, with younger women facing more hormone imbalances and older women dealing with more metabolic issues.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

More severe hair loss links to thicker heart fat, suggesting possible heart disease risk.

Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.

Skin aging reflects overall body aging and can indicate internal health conditions.

High Lipid Accumulation Product levels are linked to more hirsutism in women with Polycystic Ovary Syndrome.

Lipid Accumulation Product and Free Androgens Index are effective for assessing fatty liver disease risk in women with Polycystic Ovary Syndrome.

Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Thallium, mercury, selenium, and colchicine strongly cause hair loss.

Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.

Antioxidant-rich diets may reduce hair loss risk, while pro-inflammatory diets may increase it, especially in women.

High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.

High Nesfatin-1 and low Vitamin D may increase blood pressure and heart rate in women with PCOS.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Relatives of women with PCOS symptoms are more likely to have similar health issues.

A young woman developed a vision-threatening eye condition after using minoxidil for hair loss, which improved when she stopped the medication.