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    Glossary Hair Follicle Bulge

    specific region housing stem cells for hair growth

    The hair follicle bulge is a specific region located in the outer root sheath of the hair follicle. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration, as well as for repairing the skin after injury. This area is essential for the cyclical nature of hair growth and plays a significant role in conditions like alopecia.

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    1. Bulge cells of human hair follicles: segregation, cultivation and properties Colloids and Surfaces B: Biointerfaces · 2006 · 27 citations
    2. BULGE CELLS OF RAT HAIR FOLLICLES: ISOLATION, CULTIVATION, MORPHOLOGICAL AND BIOLOGICAL FEATURES 2010 · 17 citations
    3. Isolation of Mouse Hair Follicle Bulge Stem Cells and Their Functional Analysis in a Reconstitution Assay Methods in molecular biology · 2016 · 7 citations
    4. Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury 2020 · 4 citations
    5. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020 · 1 citations
    6. 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury Journal of Investigative Dermatology · 2018 · 1 citations
    7. Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells International Journal of Molecular Sciences · 2025
    8. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles Differentiation · 1994 · 130 citations
    9. Characterization of Hair Follicle Bulge in Human Fetal Skin: The Human Fetal Bulge Is a Pool of Undifferentiated Keratinocytes Journal of Investigative Dermatology · 1995 · 96 citations
    10. Canine hair‐follicle keratinocytes enriched with bulge cells have the highly proliferative characteristic of stem cells Veterinary Dermatology · 2009 · 37 citations
    11. Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy 2007 · 23 citations
    12. Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata 2010 · 20 citations
    13. The Hair Follicle Bulge: A Niche for Adult Stem Cells Microscopy and Microanalysis · 2011 · 19 citations
    14. Anagen hair follicle repair: Timely regenerative attempts from plastic extra‐bulge epithelial cells Experimental Dermatology · 2019 · 18 citations
    15. Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells Dermatology · 2007 · 16 citations
    16. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    17. Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development Frontiers in cell and developmental biology · 2020 · 10 citations
    18. Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation International journal of oncology · 2009 · 8 citations
    19. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles Laboratory Investigation · 2016 · 7 citations
    20. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    21. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    22. Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation Journal of Cutaneous Pathology · 2019 · 4 citations
    23. Identification of Bulge Stem Cells in Mouse and Human Hair Follicles Microscopy research · 2018 · 4 citations
    24. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    25. Bulge-Derived Epithelial Cells Isolated from Human Hair Follicles Using Enzymatic Digestion or Explants Result in Comparable Tissue-Engineered Skin International Journal of Molecular Sciences · 2025 · 1 citations
    26. Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation Stem Cell Reviews and Reports · 2026
    27. Regenerative potential of CD200- subpopulations of hair follicle bulge Frontiers in Cell and Developmental Biology · 2026
    28. Regenerative potential of CD200- subpopulations of hair follicle bulge Institutional Repositories DataBase (IRDB) · 2026
    29. 1435 Enzymatic digestion of scalp hair follicle bulge allows to have more bulge-derived stem keratinocytes than explant isolation 2023
    30. 599 PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity 2019