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    Glossary Hair Follicle Bulge

    specific region housing stem cells for hair growth

    The hair follicle bulge is a specific region located in the outer root sheath of the hair follicle. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration, as well as for repairing the skin after injury. This area is essential for the cyclical nature of hair growth and plays a significant role in conditions like alopecia.

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    Research 30 of 1000+

    1. 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury Journal of Investigative Dermatology · 2018 · 1 citations
    2. Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells International Journal of Molecular Sciences · 2025
    3. Canine hair‐follicle keratinocytes enriched with bulge cells have the highly proliferative characteristic of stem cells Veterinary Dermatology · 2009 · 37 citations
    4. Bulge cells of human hair follicles: segregation, cultivation and properties Colloids and Surfaces B: Biointerfaces · 2006 · 27 citations
    5. The Hair Follicle Bulge: A Niche for Adult Stem Cells Microscopy and Microanalysis · 2011 · 19 citations
    6. Anagen hair follicle repair: Timely regenerative attempts from plastic extra‐bulge epithelial cells Experimental Dermatology · 2019 · 18 citations
    7. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    8. Bulge-Derived Epithelial Cells Isolated from Human Hair Follicles Using Enzymatic Digestion or Explants Result in Comparable Tissue-Engineered Skin International Journal of Molecular Sciences · 2025 · 1 citations
    9. Characterization of Hair Follicle Bulge in Human Fetal Skin: The Human Fetal Bulge Is a Pool of Undifferentiated Keratinocytes Journal of Investigative Dermatology · 1995 · 96 citations
    10. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations
    11. 599 PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity 2019
    12. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles Differentiation · 1994 · 130 citations
    13. Epithelial skirt and bulge of human facial vellus hair follicles and and associated Merkel cell-nerve complex Archives of Dermatological Research · 1993 · 48 citations
    14. Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata 2010 · 20 citations
    15. BULGE CELLS OF RAT HAIR FOLLICLES: ISOLATION, CULTIVATION, MORPHOLOGICAL AND BIOLOGICAL FEATURES 2010 · 17 citations
    16. Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells Dermatology · 2007 · 16 citations
    17. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    18. Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development Frontiers in cell and developmental biology · 2020 · 10 citations
    19. Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation International journal of oncology · 2009 · 8 citations
    20. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles Laboratory Investigation · 2016 · 7 citations
    21. Isolation of Mouse Hair Follicle Bulge Stem Cells and Their Functional Analysis in a Reconstitution Assay Methods in molecular biology · 2016 · 7 citations
    22. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    23. Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury 2020 · 4 citations
    24. Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation Journal of Cutaneous Pathology · 2019 · 4 citations
    25. Identification of Bulge Stem Cells in Mouse and Human Hair Follicles Microscopy research · 2018 · 4 citations
    26. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    27. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020 · 1 citations
    28. Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation Stem Cell Reviews and Reports · 2026
    29. Regenerative potential of CD200- subpopulations of hair follicle bulge Frontiers in Cell and Developmental Biology · 2026
    30. LB1029 The common fragrance, linalool, promotes core hair follicle pathology events associated with frontal fibrosing alopecia through activating a cognate olfactory receptor in the bulge Journal of Investigative Dermatology · 2024