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The supplement highlighted advancements and challenges in plastic and reconstructive surgery, including the impact of smoking, chemotherapy, and new treatments like Tafluprost for hair loss.

Wound healing is complex and requires more research to enhance treatment methods.

New treatments for skin and hair repair show promise, but further improvements are needed.

PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Human skin can make serotonin and melatonin.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Different types of skin cells play specific roles in development, healing, and cancer.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.