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The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.