October 2013 in “The New Scientist” New hair growth from skin cells may help cure baldness.
April 2012 in “The Journal of Urology” In this prospective cohort study, male pattern baldness was identified as an independent predictor of prostate cancer, while the 2D:4D finger ratio was not associated with the cancer risk.
Targeting a specific lipid could help treat male pattern baldness.
This study found that neurotrophins produced by balding dermal papilla cells inhibited both their proliferation and hair follicle growth in vitro, suggesting a potential role in androgenetic alopecia.
April 2011 in “The FASEB Journal” This case study will explore Minoxidil's effectiveness and cost-efficiency in treating different types of baldness, without providing new clinical findings.
January 2011 in “The Internet Journal of Pharmacology” This paper reviews Minoxidil's use for baldness treatment but reports no new findings; it also raises questions on its efficacy, permanence, cost-effectiveness, demographic benefit, and potential adverse effects.
The document concludes that Androgenic Alopecia is a type of hair loss, commonly known as baldness.
Hair loss should be medically treated, as non-medical treatments are ineffective and hair loss can indicate serious health issues.
April 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Bald men with male pattern baldness still have hair stem cells, but lack certain cells needed for hair growth.
January 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Bald men with male pattern baldness still have hair stem cells, but lack certain cells needed for hair growth.
January 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Bald men with male pattern baldness still have hair stem cells, but lack certain cells needed to grow hair.
December 2021 in “Biomarkers” This study found that men with early-onset male pattern alopecia did not significantly differ from healthy individuals in cardiovascular and metabolic measures, but hsCRP and galectin-3 were linked to cardiovascular risk factors in those with the condition.
This study reported that paracrine factors, such as IGF-I and SCF, were reduced in balding hair follicles compared to non-balding ones, while inhibitory factors like TGFß-1 were increased, providing insights into the androgen action in hair follicles.
124 citations
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April 1992 in “Journal of Endocrinology/Journal of endocrinology” This study observed that cells from androgen-sensitive areas like the beard and scrotum showed higher androgen receptor levels compared to those from non-balding scalp areas, supporting the role of dermal papilla in follicle growth responses to androgens.
54 citations
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May 1998 in “Urology” This study demonstrates that patients with benign prostatic hyperplasia have a higher severity and frequency of male pattern baldness compared to a control group.
32 citations
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December 2004 in “BMC Public Health” This study found that trained observers using the Hamilton-Norwood classification were very reliable in assessing balding patterns, while men's self-assessments were moderately accurate compared to observers.
30 citations
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May 2018 in “Experimental Dermatology” This article reviews the cellular dynamics affecting dermal papilla size in androgenetic alopecia and suggests targeting DP size could improve therapies, but it presents no new clinical data.
29 citations
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February 2004 in “Experimental and Clinical Endocrinology & Diabetes” This study suggests that many men with premature balding exhibit a hormonal pattern similar to some aspects of polycystic ovary syndrome in women.
26 citations
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January 2013 in “BMJ Open” This meta-analysis reports that vertex baldness is associated with an increased risk of coronary heart disease, particularly in younger men, while no significant link was found for frontal baldness.
26 citations
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June 2000 in “Journal of The American Academy of Dermatology” This study found that older men with vertex balding had lower levels of IGFBP-3 and higher levels of IGF-1 in their plasma.
21 citations
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August 2000 in “Dermatologic Surgery” This source reports that hair surgeons can now regularly and significantly reduce damage to existing hair follicles in early-stage pattern baldness patients, helping preserve hair during treatment with finasteride or minoxidil.
20 citations
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January 1979 in “JAMA” In this study, fiber implantation for pattern baldness was deemed ineffective and resulted in complications such as infection, scarring, and permanent hair loss, making it an unacceptable treatment option.
19 citations
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January 1997 in “Endocrinology” This study observed that testosterone inhibits hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps are present, with antiandrogen RU 58841 reversing this effect.
15 citations
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March 1981 in “Journal of The American Academy of Dermatology” This study found that fiber implantation for pattern baldness frequently led to complications, including infection and scarring, and poses carcinogenesis risks, leading authorities to discourage its use.
13 citations
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November 2010 in “Experimental Dermatology” This study found that L-ascorbic acid 2-phosphate could reduce DHT-induced DKK-1 expression in balding scalp cells, suggesting potential for treating androgen-driven hair loss.
7 citations
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June 2021 in “Trends in Food Science and Technology” This commentary reviews potential dietary and mineral influences on androgenetic alopecia and suggests considering a diet low in cholesterol and glycaemic index with improved glucose control and magnesium fortification, without new clinical results.
7 citations
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October 2017 in “Urologic Oncology: Seminars and Original Investigations” This meta-analysis found that male pattern baldness is associated with an increased risk of aggressive prostate cancer and benign prostatic hyperplasia.
7 citations
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March 1999 in “PubMed” This article discusses the prevention and potential regrowth of common baldness using current treatments but reports no new clinical results.
6 citations
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June 2021 in “Journal of health psychology” This review found that commercial influences may affect how male baldness is represented as a disease and how treatment options are presented, often omitting limitations.
6 citations
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March 1991 in “PubMed” This review summarizes the clinical and endocrinologic features of androgenetic alopecia and mentions potential treatments, but it reports no new findings.